Detailed information of TA system TA039827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 821685..822730
• Replicon: chromosome
• Accession: NZ_AP024906
• Organism: Vibrio ruber strain LMG 23124

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: OCU42_RS18665
• Protein ID: WP_077332948.1
• Coordinates: 821685..822263 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: OCU42_RS18670
• Protein ID: WP_077332946.1
• Coordinates: 822248..822730 (+)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU42_RS18655	816714..817889	-	1176	WP_077332952.1	family 16 glycosylhydrolase	-
OCU42_RS18660	818775..821132	+	2358	WP_077332950.1	glycoside hydrolase family 3 N-terminal domain-containing protein	-
OCU42_RS18665	821685..822263	+	579	WP_077332948.1	hypothetical protein	Toxin
OCU42_RS18670	822248..822730	+	483	WP_077332946.1	helix-turn-helix transcriptional regulator	Antitoxin
OCU42_RS18675	823008..823886	+	879	WP_077332944.1	HEPN domain-containing protein	-
OCU42_RS18680	824304..824468	-	165	WP_162841936.1	hypothetical protein	-
OCU42_RS18685	824484..825197	-	714	WP_077332942.1	zeta toxin family protein	-
OCU42_RS18690	825256..825987	-	732	WP_205409403.1	SprT family zinc-dependent metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-139)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 22120.32 Da
• Isoelectric Point: 4.5564

>T39827 WP_077332948.1 NZ_AP024906:821685-822263 [Vibrio ruber]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKYLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADTLSDLVPKEVLLQELEVTASKCIDLKQ
RLALRGVPEQILEMPAVGLNYIPEKLTKWGLL

Nucleotide

• Length: 579 bp

>T39827 NZ_AP024906:821685-822263 [Vibrio ruber]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGCGGTGCTAGTAGACGGTACTGGGTTAAATACCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCGGACA
CCTTATCTGATCTCGTGCCAAAAGAAGTGTTATTACAAGAGCTAGAGGTTACTGCAAGTAAATGCATTGACTTAAAGCAG
AGACTAGCGTTACGAGGAGTACCAGAACAAATCTTGGAGATGCCAGCCGTTGGACTTAATTATATACCAGAAAAGCTCAC
TAAATGGGGGCTACTATGA

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17548.14 Da
• Isoelectric Point: 11.1354

>AT39827 WP_077332946.1 NZ_AP024906:822248-822730 [Vibrio ruber]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTNATHSTKERSQLNTPTRSKTSKNTKAVSAAERKTEANKIIKHLLLG
ELTQGRALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPAVLKSLLIDGEAG

Nucleotide

• Length: 483 bp

>AT39827 NZ_AP024906:822248-822730 [Vibrio ruber]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACGGTGGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGACTGGGACGAATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACACCAAAGCAGTAAGTGCAGCAGAACGCAAAACCGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCGAGCGTTGAAAAGTTTGCGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
CGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AACCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGCTGTGTTAAAATCGCTATTAATAGATGGTGAGGCTGGG
TAA