Detailed information of TA system TA039825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 2007359..2007909
• Replicon: chromosome
• Accession: NZ_AP024905
• Organism: Vibrio ruber strain LMG 23124

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCU42_RS08920
• Protein ID: WP_077337494.1
• Coordinates: 2007610..2007909 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1R4LT34
• Locus tag: OCU42_RS08915
• Protein ID: WP_059120589.1
• Coordinates: 2007359..2007601 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU42_RS08890	2002533..2002796	-	264	WP_235862919.1	hypothetical protein	-
OCU42_RS08895	2002789..2003037	-	249	WP_077337630.1	helix-turn-helix domain-containing protein	-
OCU42_RS08900	2003131..2004033	-	903	WP_077337629.1	hypothetical protein	-
OCU42_RS08905	2004544..2005485	+	942	WP_139344162.1	hypothetical protein	-
OCU42_RS08910	2005542..2006777	-	1236	WP_261855928.1	site-specific integrase	-
OCU42_RS08915	2007359..2007601	+	243	WP_059120589.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCU42_RS08920	2007610..2007909	+	300	WP_077337494.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCU42_RS08925	2008039..2008335	-	297	WP_139344150.1	hypothetical protein	-
OCU42_RS08930	2008783..2010180	-	1398	WP_077337498.1	SLC13 family permease	-
OCU42_RS08935	2010252..2011097	+	846	WP_077337492.1	helix-turn-helix transcriptional regulator	-
OCU42_RS08940	2011134..2012534	-	1401	WP_077337491.1	APC family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11591.13 Da
• Isoelectric Point: 8.1302

>T39825 WP_077337494.1 NZ_AP024905:2007610-2007909 [Vibrio ruber]
MHHNQYRLSHLAQAHLRKVKNYTISHFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYSNGFYFPIGEHTAYFTKEDG
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T39825 NZ_AP024905:2007610-2007909 [Vibrio ruber]
ATGCACCATAACCAATATAGACTAAGCCATCTAGCTCAAGCTCATCTACGCAAAGTAAAAAATTATACCATCAGCCACTT
TTCTGAACTTCAGTGGCAACGCTACAAAGAAACACTACTCTCAGGCTTTCAAATGCTCGCTGATAACCCGGACTTGGGAC
GAAGTTGCCATGAAATATACAGTAACGGGTTTTACTTTCCGATTGGGGAACATACTGCTTATTTCACAAAGGAAGATGGT
TTTATCCTCGTCGTTGCTGTGTTGGGACAATCTCAATTACCACAAAACCACCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9144.52 Da
• Isoelectric Point: 5.1116

>AT39825 WP_059120589.1 NZ_AP024905:2007359-2007601 [Vibrio ruber]
MRTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKAEYLKHCFIAAKDDLAKDDIVDGKDFLSEL

Nucleotide

• Length: 243 bp

>AT39825 NZ_AP024905:2007359-2007601 [Vibrio ruber]
ATGCGGACATTAACAGCAAATGACGCTAAACGAAATTTTGGTGAGTTGCTTTTAAATGCTCAACGTCAGCCAATTAAGAT
CAGTAAAAATAGTAAAGATGCAGTTGTCGTTATGTCTATACATGACTACGAGGAACTTGAGATGATGAAAGCTGAGTACC
TCAAACACTGCTTCATCGCCGCCAAAGATGACTTAGCAAAAGATGATATCGTTGATGGTAAAGACTTTTTGAGTGAGCTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A1R4LT34