Detailed information of TA system TA039817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1494423..1494973
• Replicon: chromosome
• Accession: NZ_AP024903
• Organism: Vibrio rhizosphaerae strain LMG 23790

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCV37_RS06370
• Protein ID: WP_261888136.1
• Coordinates: 1494423..1494722 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1R4LT34
• Locus tag: OCV37_RS06375
• Protein ID: WP_059120589.1
• Coordinates: 1494731..1494973 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV37_RS06355	1489808..1490653	-	846	WP_038181250.1	helix-turn-helix transcriptional regulator	-
OCV37_RS06360	1490736..1492133	+	1398	WP_038181179.1	SLC13 family permease	-
OCV37_RS06365	1492165..1492356	-	192	WP_261888135.1	hypothetical protein	-
OCV37_RS06370	1494423..1494722	-	300	WP_261888136.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV37_RS06375	1494731..1494973	-	243	WP_059120589.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV37_RS06380	1496032..1496178	-	147	WP_157634856.1	hypothetical protein	-
OCV37_RS06385	1496364..1496699	+	336	WP_038178288.1	hypothetical protein	-
OCV37_RS06390	1496699..1497115	+	417	WP_038178289.1	hypothetical protein	-
OCV37_RS06395	1497410..1498288	+	879	WP_038178436.1	HEPN domain-containing protein	-
OCV37_RS06400	1498932..1499396	+	465	WP_038178291.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11690.26 Da
• Isoelectric Point: 8.8574

>T39817 WP_261888136.1 NZ_AP024903:c1494722-1494423 [Vibrio rhizosphaerae]
MHHNQYRLSHLAQAHLRKVKNYTISHFSELQWQRYKETLLSGFQMLADNPDLRRSCHEIYSNGFYFPIGEHTAYFTKEDG
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T39817 NZ_AP024903:c1494722-1494423 [Vibrio rhizosphaerae]
ATGCACCATAACCAATATAGACTAAGCCATCTAGCTCAAGCTCATCTACGCAAAGTAAAAAATTATACCATCAGCCACTT
TTCTGAACTTCAGTGGCAACGCTACAAAGAAACACTACTCTCAGGCTTTCAAATGCTCGCTGATAACCCGGACTTGAGAC
GAAGTTGCCATGAAATATACAGTAACGGGTTTTACTTTCCGATTGGGGAACATACTGCTTATTTCACAAAGGAAGATGGT
TTTATCCTCGTCGTTGCTGTGTTGGGACAATCTCAATTACCACAAAACCACCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9144.52 Da
• Isoelectric Point: 5.1116

>AT39817 WP_059120589.1 NZ_AP024903:c1494973-1494731 [Vibrio rhizosphaerae]
MRTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKAEYLKHCFIAAKDDLAKDDIVDGKDFLSEL

Nucleotide

• Length: 243 bp

>AT39817 NZ_AP024903:c1494973-1494731 [Vibrio rhizosphaerae]
ATGCGGACATTAACAGCAAATGACGCTAAACGAAATTTTGGTGAGTTGCTTTTAAATGCTCAACGTCAACCAATTAAGAT
CAGTAAAAATAGTAAAGATGCAGTTGTCGTTATGTCTATACATGACTACGAGGAACTTGAGATGATGAAAGCTGAGTACC
TCAAACACTGCTTCATCGCCGCCAAAGATGACTTAGCAAAAGATGATATCGTTGATGGTAAAGACTTTTTGAGTGAGCTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A1R4LT34