Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 551618..553164 Replicon chromosome
Accession NZ_AP024901
Organism Vibrio rarus strain LMG 23674

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCU56_RS15480 Protein ID WP_261874861.1
Coordinates 551618..552919 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCU56_RS15485 Protein ID WP_261874862.1
Coordinates 552919..553164 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU56_RS15445 547319..548911 - 1593 WP_261874857.1 alkyl hydroperoxide reductase subunit F -
OCU56_RS15450 549124..549681 - 558 WP_261874858.1 alkyl hydroperoxide reductase subunit C -
OCU56_RS15455 549800..550045 - 246 Protein_481 type II toxin-antitoxin system RelE/ParE family toxin -
OCU56_RS15460 550229..550735 - 507 WP_261874859.1 GNAT family N-acetyltransferase -
OCU56_RS15465 550726..550992 - 267 WP_261874860.1 DUF1778 domain-containing protein -
OCU56_RS15470 551257..551440 - 184 Protein_484 type II toxin-antitoxin system YoeB family toxin -
OCU56_RS15475 551433..551617 - 185 Protein_485 type II toxin-antitoxin system Phd/YefM family antitoxin -
OCU56_RS15480 551618..552919 - 1302 WP_261874861.1 type II toxin-antitoxin system HipA family toxin Toxin
OCU56_RS15485 552919..553164 - 246 WP_261874862.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OCU56_RS15490 553667..554104 - 438 WP_261874863.1 helix-turn-helix domain-containing protein -
OCU56_RS15495 554115..554327 - 213 WP_261874864.1 DUF4258 domain-containing protein -
OCU56_RS15500 554657..554758 + 102 WP_261875584.1 transposase -
OCU56_RS15505 554970..556385 - 1416 WP_261874865.1 hypothetical protein -
OCU56_RS15510 556466..557503 + 1038 Protein_492 IS256 family transposase -
OCU56_RS15515 557574..558023 + 450 WP_261875585.1 HipA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 556598..557503 905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48599.34 Da        Isoelectric Point: 7.7639

>T39815 WP_261874861.1 NZ_AP024901:c552919-551618 [Vibrio rarus]
MQKLTAYMNGELVGTLEKQKNGAHSFQYDKNWLTNAVTRPISLSLKLQLPAITSDAVINYFDNLLPDSPQVRDRIVARYK
APSKQPFDLLKEIGKDSVGAIALLPPEVLYKKEPLSYEVLNEKKLESVLSAYKSDIPLGMLEEEEDFRISVAGAQEKTAL
LFVDGQWCIPKGHTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELARALGFAVPNVHIIKTGSIKALAVERFDRRW
TKDRAGLLRLPQEDMCQVFGMPSSIKYESQGGPEIAQIMELLMGSSNAIEDRYNFMRFQVFQWLIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRKLKLAMGLKATKGKKYEICKILPRHFLDTAKVVNFSQDTMQEVIDEMKGALP
KAMLQVSAALPEDFPEHIANSIFENTEKIVKKI

Download         Length: 1302 bp

>T39815 NZ_AP024901:c552919-551618 [Vibrio rarus]
ATGCAGAAGCTAACCGCATACATGAATGGTGAACTTGTTGGCACTCTAGAGAAACAAAAGAATGGTGCGCACAGTTTTCA
ATATGATAAAAACTGGTTGACCAATGCGGTGACTCGGCCAATCTCATTGTCTTTAAAACTTCAATTACCAGCCATCACTT
CCGATGCAGTTATAAACTATTTTGACAATCTCTTGCCAGACAGTCCTCAAGTCAGAGATAGAATCGTTGCTAGGTACAAA
GCACCATCCAAACAACCCTTTGATCTCCTGAAAGAAATAGGAAAAGACAGTGTTGGTGCAATTGCTTTACTTCCTCCAGA
AGTTCTTTATAAAAAAGAGCCACTTAGCTACGAAGTTCTGAATGAAAAAAAACTAGAATCGGTTCTTTCTGCATACAAGT
CTGATATTCCACTCGGTATGCTTGAAGAAGAGGAAGACTTTAGAATCTCAGTCGCAGGTGCTCAAGAGAAAACGGCTCTA
CTATTCGTTGATGGGCAATGGTGTATACCGAAAGGTCACACGCCGACGACCCACATAATCAAACTGCCTATTGGAGAGAT
CCAGCAAGCGAACGCGACCCTCGATCTCAAGGATAGCGTAGAAAACGAGTACCTTTGCATTGAGCTAGCTAGAGCTCTTG
GTTTCGCAGTTCCCAACGTTCATATAATCAAAACTGGCAGCATCAAAGCTTTAGCGGTAGAGCGTTTTGACAGGCGCTGG
ACAAAAGACAGAGCAGGATTACTACGCTTGCCTCAAGAAGATATGTGCCAAGTATTTGGTATGCCATCGTCGATTAAGTA
CGAATCTCAAGGCGGTCCAGAGATAGCACAGATAATGGAGTTGTTAATGGGATCAAGCAATGCGATAGAAGATCGATATA
ACTTCATGAGGTTTCAAGTCTTTCAATGGCTCATTGGAGCGACAGATGGGCATGCTAAGAACTTTTCTATCTATATTGAT
AGGGGAGGAAGCTATAGACTTACTCCATTCTACGATATTTTGTCAGCTTACCCACTACTGGGGGGGAAAGGGCTCAATAT
CAGAAAGTTAAAGCTGGCGATGGGATTGAAGGCAACTAAAGGCAAGAAGTATGAAATCTGTAAAATCCTACCTCGCCACT
TTTTAGACACAGCTAAAGTTGTAAACTTTAGCCAAGACACTATGCAAGAGGTAATTGATGAAATGAAAGGTGCTTTGCCT
AAGGCAATGTTACAAGTCAGTGCTGCATTGCCTGAAGACTTTCCTGAGCATATCGCTAATTCAATTTTTGAGAATACTGA
GAAAATAGTTAAGAAGATTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9232.53 Da        Isoelectric Point: 6.2261

>AT39815 WP_261874862.1 NZ_AP024901:c553164-552919 [Vibrio rarus]
MIYSPKQLADMMLLIRQKNGWTQSELAKTVGIKQATISNFENNPNKTTLSTFFKLAQAMDLTLSIQERSQVAPLNENDDN
W

Download         Length: 246 bp

>AT39815 NZ_AP024901:c553164-552919 [Vibrio rarus]
ATGATATATAGCCCAAAACAATTAGCAGATATGATGCTACTGATACGCCAGAAGAATGGATGGACACAATCAGAACTAGC
AAAAACAGTGGGTATCAAGCAAGCGACGATCTCGAACTTCGAAAACAACCCTAACAAAACAACTCTTTCTACCTTCTTTA
AACTTGCCCAGGCAATGGATCTCACATTGAGTATCCAAGAAAGATCACAGGTAGCTCCGTTAAATGAAAATGATGATAAT
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References