Detailed information of TA system TA039810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 891469..891985
• Replicon: chromosome
• Accession: NZ_AP024900
• Organism: Vibrio rarus strain LMG 23674

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: OCU56_RS04235
• Protein ID: WP_261874299.1
• Coordinates: 891716..891985 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: U2ZH00
• Locus tag: OCU56_RS04230
• Protein ID: WP_005526636.1
• Coordinates: 891469..891723 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU56_RS04200	886474..886746	+	273	WP_261874294.1	hypothetical protein	-
OCU56_RS04205	887045..887188	+	144	WP_261874771.1	helix-turn-helix domain-containing protein	-
OCU56_RS04210	887363..888619	+	1257	WP_261874295.1	carbohydrate porin	-
OCU56_RS04215	888689..890068	+	1380	WP_261874296.1	amidohydrolase family protein	-
OCU56_RS04220	890146..890778	+	633	WP_261874297.1	DUF3299 domain-containing protein	-
OCU56_RS04225	890985..891164	-	180	WP_261874298.1	hypothetical protein	-
OCU56_RS04230	891469..891723	+	255	WP_005526636.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OCU56_RS04235	891716..891985	+	270	WP_261874299.1	Txe/YoeB family addiction module toxin	Toxin
OCU56_RS04240	892075..892488	+	414	WP_261874300.1	VOC family protein	-
OCU56_RS04245	892860..893984	-	1125	WP_261874301.1	fatty acid desaturase	-
OCU56_RS04250	894265..894639	+	375	WP_261874302.1	MmcQ/YjbR family DNA-binding protein	-
OCU56_RS04280	895753..896838	+	1086	WP_261874303.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10550.87 Da
• Isoelectric Point: 8.8578

>T39810 WP_261874299.1 NZ_AP024900:891716-891985 [Vibrio rarus]
MSSSQRLLSWTDEAWGDYLYWQSQDKKTLKRINKLINDVKRSSFEGIGKPESLKENLSGFWSRRIDDTNRLVYAIDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T39810 NZ_AP024900:891716-891985 [Vibrio rarus]
ATGAGTAGTAGTCAACGTTTACTATCGTGGACTGATGAGGCTTGGGGGGACTATCTGTATTGGCAAAGCCAAGATAAGAA
AACACTCAAGCGTATCAACAAACTCATTAATGATGTTAAGCGTTCTTCTTTTGAGGGGATTGGTAAACCAGAGTCGTTGA
AAGAGAATTTATCTGGCTTTTGGTCTCGCCGCATTGACGACACAAATAGACTTGTTTACGCGATCGATGATCAAGCAATC
ACAATAATATCATGCCGCTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9453.60 Da
• Isoelectric Point: 5.0623

>AT39810 WP_005526636.1 NZ_AP024900:891469-891723 [Vibrio rarus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT39810 NZ_AP024900:891469-891723 [Vibrio rarus]
ATGAGAATTGTATCTTTTACTGAGGCTAGAAATGGTCTTAAAGCTGTTTTAGATGGTGTAGTTAATGACGCAGACACAAC
AGTCATTACACGTCGTGACTCTGAAGATGCTGTGGTTATGTCTTTAGACTACTACAACAGTCTTATGGAGACAGTGCACT
TACTACGCTCTCCTCAAAATGCTGAACACCTAAACCGATCAATAGCACAGTACCGTGCTGGTAAAACAACCGCACGAGAG
TTGATTGATGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A244CM06