Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2781940..2783513 Replicon chromosome
Accession NZ_AP024895
Organism Vibrio porteresiae DSM 19223 strain MSSRF30

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCV11_RS12715 Protein ID WP_261893265.1
Coordinates 2782188..2783513 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCV11_RS12710 Protein ID WP_261893263.1
Coordinates 2781940..2782188 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV11_RS12690 2777571..2778155 - 585 WP_261893257.1 LysE family translocator -
OCV11_RS12695 2778265..2778708 + 444 WP_261893258.1 Lrp/AsnC family transcriptional regulator -
OCV11_RS12700 2779129..2780640 + 1512 WP_261893260.1 PTS transporter subunit EIIC -
OCV11_RS12705 2780641..2781636 - 996 WP_261893262.1 LacI family DNA-binding transcriptional regulator -
OCV11_RS12710 2781940..2782188 + 249 WP_261893263.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OCV11_RS12715 2782188..2783513 + 1326 WP_261893265.1 type II toxin-antitoxin system HipA family toxin Toxin
OCV11_RS12720 2783610..2785298 - 1689 WP_261893266.1 zinc ribbon domain-containing protein -
OCV11_RS12725 2785442..2787295 - 1854 WP_261893267.1 3'-5' exonuclease -
OCV11_RS12730 2787528..2788106 + 579 WP_261893268.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-61)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49501.97 Da        Isoelectric Point: 7.0040

>T39805 WP_261893265.1 NZ_AP024895:2782188-2783513 [Vibrio porteresiae DSM 19223]
MASLNAYMNGLLVGELIKLPNGAHQFQYDKAWVDSPMGRPLSLSLPLSYSKHTSDKVINYFDNLLPDRTEIRDRIVTRYQ
TPSRQAFDLLCAVGKDSVGAISLMTPDSQPNVQRLDFELLSKEKLQRVLISYQSSIPLGMLEDEDDFRISVAGAQEKTAL
LKMDGQWCIPQGSTPTSHIVKLPIGEIKQPSATLDMSDSVENEYLCLQLAREMGFDVPDAEIIHCDEVKAIAIKRFDRRW
SNDKTWLLRIPQEDMCQASGLSSSIKYEADGGPSIKDIMNLLMGSSKALADREAFMRFQVFQWIIGATDGHAKNFSIFIE
PQGGYHLTPFYDIISAYTVLGGKGLNIRSLKLAMGLKASKGKKYRLDKIQPRHFLATAEECGFSKQKMTEILEEFATEFP
KAVERVKHNLPVDFPKHVSEAIFSHSLKMVKKSGLVNKEAE

Download         Length: 1326 bp

>T39805 NZ_AP024895:2782188-2783513 [Vibrio porteresiae DSM 19223]
ATGGCTTCTCTCAATGCCTACATGAATGGATTACTGGTTGGCGAGTTAATCAAATTACCCAACGGAGCACATCAGTTTCA
ATACGATAAAGCGTGGGTAGATTCGCCCATGGGGCGTCCACTTTCCTTGTCTCTGCCGTTAAGTTATTCAAAGCATACCT
CAGATAAGGTCATCAATTATTTTGATAACTTATTGCCGGATAGAACTGAGATTCGTGATCGTATCGTAACTCGATATCAA
ACACCTTCACGCCAAGCATTTGACCTACTCTGTGCCGTTGGTAAAGACAGTGTCGGCGCAATATCGCTGATGACACCAGA
TAGCCAGCCTAATGTTCAACGGCTTGATTTTGAGCTGCTAAGTAAAGAGAAATTACAACGCGTCCTTATTTCTTATCAGT
CCAGCATTCCCCTAGGCATGCTGGAAGATGAAGACGATTTCCGCATTTCAGTTGCCGGCGCTCAAGAAAAAACAGCACTG
TTAAAAATGGATGGACAATGGTGCATCCCTCAAGGCTCCACCCCAACGTCTCACATCGTCAAATTGCCTATCGGTGAAAT
CAAACAGCCAAGTGCAACGTTGGATATGAGCGATAGTGTCGAGAACGAGTATTTATGCCTACAACTGGCAAGAGAAATGG
GATTTGACGTTCCAGATGCAGAAATCATCCACTGTGATGAGGTAAAAGCCATCGCAATCAAGCGATTTGATCGCCGCTGG
TCTAATGATAAAACGTGGCTATTACGAATTCCTCAAGAAGATATGTGCCAAGCATCTGGGTTATCGTCATCGATAAAATA
TGAAGCCGATGGCGGACCCTCGATAAAAGATATCATGAACTTACTGATGGGATCATCGAAGGCGCTAGCAGACCGAGAAG
CGTTTATGCGCTTTCAAGTATTCCAATGGATTATTGGTGCAACCGATGGTCATGCCAAAAACTTTTCAATATTTATTGAG
CCTCAAGGTGGCTACCACCTCACTCCTTTTTACGACATTATCTCAGCCTATACAGTGCTGGGTGGTAAAGGATTAAACAT
TCGCTCGTTAAAACTCGCCATGGGATTAAAAGCATCAAAAGGGAAAAAATACCGTTTAGATAAGATCCAACCTCGACACT
TTCTTGCCACCGCAGAAGAGTGTGGTTTTAGTAAACAGAAGATGACTGAGATTCTTGAAGAATTTGCGACTGAGTTTCCT
AAAGCGGTTGAGCGAGTAAAACACAATCTCCCAGTAGATTTTCCAAAACACGTCTCAGAGGCCATTTTCAGCCACTCGCT
GAAAATGGTAAAGAAGTCGGGGCTTGTAAATAAAGAGGCTGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9340.70 Da        Isoelectric Point: 7.2009

>AT39805 WP_261893263.1 NZ_AP024895:2781940-2782188 [Vibrio porteresiae DSM 19223]
MIYSPQQLANQLKLIRTKHSLSQSELAEKVGIKQSTLSNFENHPDTTQLKTVFKIIQALELQLTVSEKEQAYVIKDPSGE
VW

Download         Length: 249 bp

>AT39805 NZ_AP024895:2781940-2782188 [Vibrio porteresiae DSM 19223]
ATGATTTATAGCCCGCAACAATTGGCCAATCAATTAAAGCTTATTCGCACTAAACATTCTCTGAGCCAATCTGAGCTTGC
TGAAAAAGTGGGAATAAAGCAGTCCACCTTATCCAATTTTGAAAATCACCCAGACACCACGCAGTTAAAAACGGTCTTCA
AAATCATTCAGGCATTGGAACTGCAACTCACTGTCAGTGAAAAAGAGCAAGCTTACGTCATCAAAGATCCTTCTGGTGAG
GTGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References