Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2461248..2463076 Replicon chromosome
Accession NZ_AP024893
Organism Vibrio plantisponsor strain CECT 7581

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCV04_RS11425 Protein ID WP_171138693.1
Coordinates 2461248..2462609 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCV04_RS11430 Protein ID WP_171138692.1
Coordinates 2462594..2463076 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV04_RS11410 2456832..2457617 - 786 WP_024374503.1 DUF4123 domain-containing protein -
OCV04_RS11415 2457614..2459593 - 1980 WP_104965430.1 type VI secretion system tip protein TssI/VgrG -
OCV04_RS11420 2459714..2460232 - 519 WP_020432677.1 type VI secretion system effector Hcp-2 -
OCV04_RS11425 2461248..2462609 + 1362 WP_171138693.1 type II toxin-antitoxin system HipA family toxin Toxin
OCV04_RS11430 2462594..2463076 + 483 WP_171138692.1 helix-turn-helix domain-containing protein Antitoxin
OCV04_RS11440 2465016..2466071 + 1056 WP_171138877.1 sensor domain-containing diguanylate cyclase -
OCV04_RS11445 2466079..2466972 - 894 WP_171138876.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-143)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51202.96 Da        Isoelectric Point: 4.8032

>T39802 WP_171138693.1 NZ_AP024893:2461248-2462609 [Vibrio plantisponsor]
MEELTIQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLGDYALEHHDKDDFHAVSLNHPVSFFFDDIGKPGWLTFLDDIM
PSGASRRYWVKYLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRSGFDHSSGSEKIWIDPYQDDNSNYDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQVERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHKGYSFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T39802 NZ_AP024893:2461248-2462609 [Vibrio plantisponsor]
ATGGAAGAACTAACCATACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCGGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTGATGACATAGGTAAACCTGGATGGTTAACGTTTCTAGACGATATTATG
CCTAGCGGTGCTAGTAGACGGTACTGGGTTAAATACCTGGATATTGAAGATCTTAGTTCTGATGAACAGGACTATGTCTT
GCTCAAATTTGGCACGATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCCCTTCCTGAACGCTACGAAGTAGCAGACA
ACCTCTATTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTAATCCTCCGATCTGGTTTCGATCATAGTTCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACTACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGCAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTATTGATCA
ACAAGTCGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACAAAGGATATAGCTTTGATACTCAAGCTTTC
GTCATTGAATGGGTTAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGACAACCACGGCAGAAATACTTCATTCTT
AAAGGGTGATGGAGTCATAAAACTTGCTCCCATTTACGATTTCGCACCAATGAAAGCTGATCCTGAAGGAATTCCAAGAA
CAACAAAATGGAAAGCCCCACTTGAGGTAGGCGGAACTTACGACTTCGTCGGAATAGCAGACACCTTATCTGATCTCGTG
CCCAAGGAAGTGTTATTAAAAGAGCTAGCGATTACAGCAAGTAAATGCGTAGGCCTAAAGCAGAGACTCGCTTTACGAGG
AGTGCCAGAACAAATCTTGGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGACTGCTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17699.46 Da        Isoelectric Point: 10.9147

>AT39802 WP_171138692.1 NZ_AP024893:2462594-2463076 [Vibrio plantisponsor]
MGTAMKKPSNKESVKDTVARLRANRNKQQPKIGKNVTHSIKEQTQLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKNLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGLLPSSPDALKSLLIDGEDR

Download         Length: 483 bp

>AT39802 NZ_AP024893:2462594-2463076 [Vibrio plantisponsor]
ATGGGGACTGCTATGAAAAAGCCAAGCAATAAGGAGTCCGTAAAAGATACGGTAGCTCGTCTAAGAGCAAACCGAAATAA
ACAGCAGCCCAAGATTGGGAAGAATGTAACTCATTCGATCAAAGAGCAAACACAACTCGATACTCCAACGAGATCGAAAG
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACCGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAGGGCCAAGCGCTGAAAAATTTACGCATTAATATACTGGGACTGAAACAGGATGTATTCGCAAGACTTGT
CGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTATAATACAGAGATTCTAAACAAGGTATTCA
AACCATTTGGCTTAAAAGTCGGACTACTCCCTTCTTCTCCCGATGCGTTAAAGTCGCTATTAATAGATGGTGAGGATAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References