Detailed information of TA system TA039801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 573653..574202
• Replicon: chromosome
• Accession: NZ_AP024886
• Organism: Vibrio neonatus strain JCM 21521

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCU38_RS14920
• Protein ID: WP_261824309.1
• Coordinates: 573653..573952 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: V5F0L5
• Locus tag: OCU38_RS14925
• Protein ID: WP_023403042.1
• Coordinates: 573960..574202 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU38_RS14895	569363..569662	-	300	WP_023403039.1	hypothetical protein	-
OCU38_RS14900	569932..570651	+	720	WP_261824306.1	hypothetical protein	-
OCU38_RS14905	570607..570906	-	300	WP_023403039.1	hypothetical protein	-
OCU38_RS14910	571579..572529	+	951	WP_261824307.1	hypothetical protein	-
OCU38_RS14915	572892..573461	+	570	WP_261824308.1	hypothetical protein	-
OCU38_RS14920	573653..573952	-	300	WP_261824309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCU38_RS14925	573960..574202	-	243	WP_023403042.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCU38_RS14930	574345..574458	-	114	Protein_419	IS110 family transposase	-
OCU38_RS14935	575236..576279	+	1044	WP_261824310.1	alpha/beta hydrolase	-
OCU38_RS14940	576499..578286	+	1788	WP_261824311.1	mechanosensitive ion channel family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11446.04 Da
• Isoelectric Point: 9.3227

>T39801 WP_261824309.1 NZ_AP024886:c573952-573653 [Vibrio neonatus]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWSNYKNTLLTGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T39801 NZ_AP024886:c573952-573653 [Vibrio neonatus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAAACTACACGGTTGAAAACTT
TTCTGAATTACAGTGGAGCAACTACAAAAACACTCTGTTAACTGGGTTTCAAATGTTAGCTGATAACCCCGGTTTAGGAA
GAAGCTGTGACGAGATATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTGGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCACCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9028.26 Da
• Isoelectric Point: 5.6926

>AT39801 WP_023403042.1 NZ_AP024886:c574202-573960 [Vibrio neonatus]
MHTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNAVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT39801 NZ_AP024886:c574202-573960 [Vibrio neonatus]
ATGCATACATTAACAGCGAATGATGCCAAACGAAATTTCGGCGAGCTACTTCTAAACGCACAACGCGAGCCAATAAAAAT
CAGCAAAAACAGTAAGGATGCTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAATACC
TCAAACACTGCTTTAAATCAGCTAAAGAAGACTTGAACAATGGAAACGCAGTTGATGGCGAAAGCTTTCTGAATTCGCTG
TAA

Structures

Antitoxin

• AlphaFold DB: V5F0L5