Detailed information of TA system TA039795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 1014877..1015643
• Replicon: chromosome
• Accession: NZ_AP024885
• Organism: Vibrio neonatus strain JCM 21521

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OCU38_RS04730
• Protein ID: WP_261823956.1
• Coordinates: 1015146..1015643 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V5FDK6
• Locus tag: OCU38_RS04725
• Protein ID: WP_023404091.1
• Coordinates: 1014877..1015149 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU38_RS04705	1010561..1010812	-	252	WP_261823952.1	hypothetical protein	-
OCU38_RS04710	1010951..1011961	-	1011	WP_261823953.1	LacI family DNA-binding transcriptional regulator	-
OCU38_RS04715	1012142..1013359	+	1218	WP_261823954.1	D-galactonate dehydratase family protein	-
OCU38_RS04720	1013441..1014574	+	1134	WP_261823955.1	Gfo/Idh/MocA family oxidoreductase	-
OCU38_RS04725	1014877..1015149	+	273	WP_023404091.1	DUF1778 domain-containing protein	Antitoxin
OCU38_RS04730	1015146..1015643	+	498	WP_261823956.1	GNAT family N-acetyltransferase	Toxin
OCU38_RS04735	1015776..1016261	-	486	WP_261823957.1	hypothetical protein	-
OCU38_RS04740	1016562..1018841	+	2280	WP_261823958.1	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18502.17 Da
• Isoelectric Point: 9.3145

>T39795 WP_261823956.1 NZ_AP024885:1015146-1015643 [Vibrio neonatus]
MMNTVLLDKAKHNRNRFNCGSEALNNYLKVMASQQAKKDNTRTFVLQDENDNTHVIGFYTLTMIPIDLKALPDKLQKKHQ
PSSSGGLIARLAVDDRYKSKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGATQFYERYGFTPFQDADNKLFITISDI
RASLG

Nucleotide

• Length: 498 bp

>T39795 NZ_AP024885:1015146-1015643 [Vibrio neonatus]
ATGATGAACACAGTACTTCTAGATAAAGCTAAACATAATAGAAACCGCTTCAATTGTGGTAGTGAGGCTTTAAACAATTA
CTTAAAAGTAATGGCTAGCCAACAAGCCAAAAAAGACAATACCCGCACCTTTGTGTTGCAGGATGAAAACGATAATACTC
ATGTTATTGGTTTCTATACTTTGACCATGATACCGATTGATTTAAAAGCATTGCCGGACAAATTACAGAAGAAACATCAG
CCATCGTCTTCTGGTGGTTTAATTGCTCGACTGGCAGTTGATGACCGATACAAAAGTAAAGGTTTTGGTGAGTGGCTTTT
GATCGATGCACTAAGAAAATTACTTGCCGCTAGCGATAGTGTCGCTTTTCCTGTGGTTATTGTAGACGCGAAAGATGGCG
CAACCCAGTTTTATGAACGCTATGGATTTACACCATTTCAAGATGCTGACAACAAGTTGTTCATCACAATATCTGATATT
CGAGCAAGCTTGGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9648.10 Da
• Isoelectric Point: 6.2809

>AT39795 WP_023404091.1 NZ_AP024885:1014877-1015149 [Vibrio neonatus]
MATTLPRITARVDADTQDLLTKAAAIAGMSSINSFVLSAAVEKAKQVIEREQALKLSQADAMLLMDALDKPATINSNLRA
AAERYDSKVQ

Nucleotide

• Length: 273 bp

>AT39795 NZ_AP024885:1014877-1015149 [Vibrio neonatus]
ATGGCGACTACATTGCCTCGGATCACAGCTAGAGTTGATGCCGATACACAAGATTTGCTGACTAAGGCGGCGGCTATTGC
TGGTATGTCTAGTATAAACTCATTTGTACTGAGTGCGGCTGTCGAGAAAGCTAAACAAGTTATCGAGCGTGAACAGGCTT
TAAAGCTAAGCCAAGCTGATGCGATGTTGTTGATGGATGCACTAGATAAACCGGCGACAATAAACAGCAACCTAAGAGCT
GCGGCCGAGCGTTACGATAGTAAAGTTCAATGA

Structures

Antitoxin

• AlphaFold DB: V5FDK6