Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 901883..902535 Replicon chromosome
Accession NZ_AP024874
Organism Vibrio gazogenes strain ATCC 29988

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M4UZZ3
Locus tag OCU45_RS19720 Protein ID WP_072955385.1
Coordinates 902356..902535 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M4V002
Locus tag OCU45_RS19715 Protein ID WP_021021012.1
Coordinates 901883..902296 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU45_RS19690 898217..898546 - 330 WP_072955392.1 hypothetical protein -
OCU45_RS19695 898788..899843 + 1056 WP_072955391.1 IS630 family transposase -
OCU45_RS19700 899863..900435 - 573 WP_131814860.1 hypothetical protein -
OCU45_RS19705 900574..900900 - 327 WP_072955387.1 hypothetical protein -
OCU45_RS19710 901047..901595 - 549 WP_072955735.1 hypothetical protein -
OCU45_RS19715 901883..902296 - 414 WP_021021012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCU45_RS19720 902356..902535 - 180 WP_072955385.1 type II toxin-antitoxin system HicA family toxin Toxin
OCU45_RS19725 902938..903219 - 282 WP_205409164.1 hypothetical protein -
OCU45_RS19730 903508..903885 - 378 WP_205409163.1 hypothetical protein -
OCU45_RS19735 903889..904839 - 951 WP_261859405.1 polysaccharide deacetylase family protein -
OCU45_RS19740 904900..905565 - 666 Protein_807 glycoside hydrolase family 11 protein -
OCU45_RS19745 906612..906902 - 291 WP_072955382.1 YkgJ family cysteine cluster protein -
OCU45_RS19750 907059..907262 - 204 WP_021021019.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 898941..899843 902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6679.92 Da        Isoelectric Point: 11.0775

>T39788 WP_072955385.1 NZ_AP024874:c902535-902356 [Vibrio gazogenes]
VKSADLINLLKKNGWELVSVRGSHHKFRHLAHDDPIIVPHPKKDLKIGLVNKIKRQAGL

Download         Length: 180 bp

>T39788 NZ_AP024874:c902535-902356 [Vibrio gazogenes]
GTGAAAAGTGCAGACTTAATTAATCTCTTGAAAAAGAACGGGTGGGAGTTAGTCAGTGTCAGAGGAAGTCATCACAAGTT
CCGACATCTAGCTCATGATGATCCGATCATTGTTCCACATCCCAAAAAAGATTTAAAAATTGGGTTGGTCAACAAAATAA
AGAGACAGGCGGGGCTGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15259.33 Da        Isoelectric Point: 4.5544

>AT39788 WP_021021012.1 NZ_AP024874:c902296-901883 [Vibrio gazogenes]
MLYPIAIDTGDKEHAYGVTFPDLPGCFSAGDTLDEALLNAKDAAEFYLEDLAEHGKLPPKAGDLSTWQKDPEYLGWAWAV
VDIDVEPFLGKSIKINATLPTLYLKKIDDLVKVHPEYKNRSHFLQIAATHEFEKLAG

Download         Length: 414 bp

>AT39788 NZ_AP024874:c902296-901883 [Vibrio gazogenes]
ATGTTATATCCCATTGCAATTGATACCGGCGATAAGGAACATGCTTACGGCGTGACGTTTCCCGATTTACCCGGATGTTT
CTCAGCCGGAGATACCTTGGATGAAGCATTGTTAAACGCAAAAGACGCTGCTGAGTTTTATTTAGAAGATTTGGCTGAAC
ACGGTAAATTACCACCGAAAGCTGGTGATCTTTCGACGTGGCAAAAAGACCCGGAATATCTCGGGTGGGCTTGGGCTGTT
GTTGATATTGATGTTGAGCCGTTTTTGGGGAAATCCATTAAGATTAATGCAACGCTCCCGACCCTTTACCTGAAAAAGAT
CGATGATTTGGTCAAGGTACATCCAGAGTACAAAAACCGTTCACATTTCTTACAAATTGCTGCTACGCATGAGTTCGAAA
AGCTGGCCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4UZZ3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4V002

References