Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 887572..888088 Replicon chromosome
Accession NZ_AP024874
Organism Vibrio gazogenes strain ATCC 29988

Toxin (Protein)


Gene name relB Uniprot ID A0A1M4V2Z8
Locus tag OCU45_RS19625 Protein ID WP_072955412.1
Coordinates 887572..887841 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1M4V2U4
Locus tag OCU45_RS19630 Protein ID WP_072955410.1
Coordinates 887834..888088 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU45_RS19595 882750..883433 - 684 WP_131814862.1 hypothetical protein -
OCU45_RS19600 883565..883984 - 420 WP_235862468.1 hypothetical protein -
OCU45_RS19605 884195..884524 - 330 WP_235862469.1 hypothetical protein -
OCU45_RS19610 885168..886049 - 882 WP_072955738.1 HEPN domain-containing protein -
OCU45_RS19615 886327..886824 - 498 WP_021020996.1 GNAT family N-acetyltransferase -
OCU45_RS19620 886927..887430 - 504 WP_072955414.1 peptide deformylase -
OCU45_RS19625 887572..887841 - 270 WP_072955412.1 Txe/YoeB family addiction module toxin Toxin
OCU45_RS19630 887834..888088 - 255 WP_072955410.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OCU45_RS19635 888236..888691 - 456 WP_072955408.1 hypothetical protein -
OCU45_RS19640 888813..888950 + 138 Protein_787 IS256 family transposase -
OCU45_RS19645 888982..889926 - 945 WP_072955406.1 DUF5677 domain-containing protein -
OCU45_RS19650 890494..890676 - 183 WP_072955404.1 hypothetical protein -
OCU45_RS19655 890996..892048 - 1053 WP_072955398.1 DctP family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 880962..901667 20705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10656.06 Da        Isoelectric Point: 9.4079

>T39787 WP_072955412.1 NZ_AP024874:c887841-887572 [Vibrio gazogenes]
MSSSQRLLSWTDESWNDYLYWRTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T39787 NZ_AP024874:c887841-887572 [Vibrio gazogenes]
ATGAGTAGTAGCCAGCGATTGCTTTCATGGACTGATGAATCTTGGAATGATTATTTATATTGGCGAACACAAGATAAAAA
GACATTAAAGCGTATAAATAAATTAATTAATGATGTAAAACGTTCACCATTTGAAGGTATCGGAAAGCCCGAGCCATTAA
AAGAAAATCTAGCCGGCTTTTGGTCACGCCGTATTGACGATACTAATCGGTTAGTTTATGCGGTTGATGACCAAGCTATC
ACAATTATTTCATGTCGTTATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9444.56 Da        Isoelectric Point: 4.5700

>AT39787 WP_072955410.1 NZ_AP024874:c888088-887834 [Vibrio gazogenes]
MKIVSFTEARNSLKAVLDGVVNDADTTVITRRDAEDAVVMSLDYYNSLMETVHLLRSPENAEHLNRSIAQYRAGQTTARD
LMDE

Download         Length: 255 bp

>AT39787 NZ_AP024874:c888088-887834 [Vibrio gazogenes]
ATGAAAATTGTATCTTTTACGGAAGCGAGAAATAGTTTAAAAGCTGTTCTCGATGGTGTCGTGAATGATGCTGATACAAC
AGTAATCACTCGCCGTGATGCAGAGGATGCAGTAGTCATGTCCTTGGATTACTACAATAGCTTGATGGAAACCGTTCATT
TACTTCGTTCTCCAGAAAACGCAGAGCATCTAAATCGTTCAATTGCTCAATATCGTGCAGGTCAAACAACAGCTCGAGAT
TTAATGGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4V2Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4V2U4

References