Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 303201..303739 Replicon chromosome
Accession NZ_AP024874
Organism Vibrio gazogenes strain ATCC 29988

Toxin (Protein)


Gene name parE Uniprot ID A0A1M4TJ95
Locus tag OCU45_RS17010 Protein ID WP_072954745.1
Coordinates 303440..303739 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1M4TJ42
Locus tag OCU45_RS17005 Protein ID WP_072954743.1
Coordinates 303201..303443 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU45_RS16985 298235..299149 - 915 WP_205409103.1 homocysteine S-methyltransferase family protein -
OCU45_RS16990 299386..299913 + 528 WP_072954737.1 PAS domain-containing protein -
OCU45_RS16995 299923..301407 + 1485 WP_077316224.1 methyl-accepting chemotaxis protein -
OCU45_RS17000 301575..302795 - 1221 WP_072954740.1 aldose 1-epimerase family protein -
OCU45_RS17005 303201..303443 + 243 WP_072954743.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
OCU45_RS17010 303440..303739 + 300 WP_072954745.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCU45_RS17015 303773..304084 - 312 WP_072954747.1 antibiotic biosynthesis monooxygenase family protein -
OCU45_RS17020 304221..304421 + 201 Protein_268 IS110 family transposase -
OCU45_RS17025 304788..305390 - 603 WP_072954750.1 nitroreductase family protein -
OCU45_RS17030 305535..306425 + 891 WP_072954753.1 LysR family transcriptional regulator -
OCU45_RS17035 306542..306736 - 195 WP_131814842.1 hypothetical protein -
OCU45_RS17040 307199..308245 - 1047 WP_131814844.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 303201..314332 11131
- flank IS/Tn - - 304221..304466 245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11719.39 Da        Isoelectric Point: 9.7945

>T39785 WP_072954745.1 NZ_AP024874:303440-303739 [Vibrio gazogenes]
MKPFQLTNRAKSDLKDIALFTYHRWGREQRNAYVKQFDETFWLLAENPDIGKNCDEIRNGYKKFPQGSHVIFYQQISSQN
IQIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T39785 NZ_AP024874:303440-303739 [Vibrio gazogenes]
ATGAAACCATTCCAACTGACCAATAGGGCGAAGTCTGATTTAAAAGACATCGCTCTATTTACCTATCACCGGTGGGGGCG
CGAACAGCGAAATGCTTACGTAAAACAATTCGACGAGACCTTTTGGCTATTAGCTGAAAACCCTGATATCGGTAAAAACT
GTGATGAAATCAGAAATGGCTACAAAAAGTTTCCTCAAGGCAGCCATGTTATTTTTTATCAACAAATCAGTAGCCAAAAT
ATTCAAATCATCAGAATCTTACATAAAAGTATGGATGTAAATCCTATATTTGGCGCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8982.96 Da        Isoelectric Point: 4.3219

>AT39785 WP_072954743.1 NZ_AP024874:303201-303443 [Vibrio gazogenes]
MAKNTSITLGEHFDSFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGLADYDLNSFINELDSEEKK

Download         Length: 243 bp

>AT39785 NZ_AP024874:303201-303443 [Vibrio gazogenes]
ATGGCTAAAAATACCAGCATTACTTTGGGTGAACACTTTGATAGCTTTATTGCTAACCAGATTCAAAGCGGACGCTATGG
TTCTGCGAGCGAAGTTATCCGCTCTGCTCTACGCTTACTTGAAACGCAAGAAACGAAAATGAACACCTTACGACAACTAC
TTGTTGAAGGTGAAGAGAGTGGTTTGGCTGACTATGACCTCAATTCGTTTATCAATGAACTCGATAGCGAAGAGAAAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4TJ95

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4TJ42

References