Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 243605..244164 Replicon chromosome
Accession NZ_AP024874
Organism Vibrio gazogenes strain ATCC 29988

Toxin (Protein)


Gene name relE Uniprot ID A0A1M4TBS6
Locus tag OCU45_RS16745 Protein ID WP_072954617.1
Coordinates 243605..243883 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1M4TC76
Locus tag OCU45_RS16750 Protein ID WP_072954620.1
Coordinates 243880..244164 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU45_RS16725 239403..240848 + 1446 WP_162841350.1 family 1 glycosylhydrolase -
OCU45_RS16730 241075..241461 - 387 WP_072954607.1 DUF5405 family protein -
OCU45_RS16735 241581..242084 - 504 WP_072954610.1 GNAT family N-acetyltransferase -
OCU45_RS16740 242131..242739 - 609 WP_072954612.1 MarC family protein -
OCU45_RS16745 243605..243883 - 279 WP_072954617.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
OCU45_RS16750 243880..244164 - 285 WP_072954620.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OCU45_RS16755 244554..245069 + 516 WP_072954622.1 adenylate kinase -
OCU45_RS16760 245120..245260 + 141 Protein_216 VOC family protein -
OCU45_RS16765 245454..246791 + 1338 WP_235862461.1 MATE family efflux transporter -
OCU45_RS16770 246901..247515 + 615 WP_072954624.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10821.39 Da        Isoelectric Point: 4.2894

>T39784 WP_072954617.1 NZ_AP024874:c243883-243605 [Vibrio gazogenes]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLSISEISMIVSYWVEGDIVHVM
RVLHQKQKFPAE

Download         Length: 279 bp

>T39784 NZ_AP024874:c243883-243605 [Vibrio gazogenes]
ATGATTTTATGGGAGGAAGAATCTCTCAATGATCGCGAAAAGATCTTCGAGTTTCTTTACGATTTTAACCCAGACGCTGC
CGAGAAAACCGATGAACTTATCGAGGCCAAAGTCGAAAACCTTTTGGAACAACCTCTTATGGGGGTACAGCGTGATGGCA
TTCGGGGACGACTTCTGAGCATTTCTGAGATATCAATGATCGTCTCGTACTGGGTTGAAGGTGATATCGTCCATGTTATG
CGCGTACTACACCAAAAACAAAAATTCCCTGCTGAGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10912.27 Da        Isoelectric Point: 9.9593

>AT39784 WP_072954620.1 NZ_AP024874:c244164-243880 [Vibrio gazogenes]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTDQVNLAFEKFDSGKAVFTDHNAAKSR
MTERKAKIRNRGKL

Download         Length: 285 bp

>AT39784 NZ_AP024874:c244164-243880 [Vibrio gazogenes]
ATGGACACTAGAATTCAATTTCGTGTTGATGAGGAAACAAAGCGTTTAGCCCAACAAATGGCTGAAAGCCAAGGTCGAAC
CTTAAGCGACGCTTGCCGTGAACTTACCGAACAACTCGCTGAGCAACAACGAAAAACGTTATCTCATGATGCATGGCTTA
CTGACCAAGTCAACCTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCTGTTTTCACTGACCATAACGCTGCGAAATCTCGA
ATGACTGAACGTAAGGCTAAGATTCGCAACCGAGGCAAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4TBS6

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4TC76

References