Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1896955..1898522 Replicon chromosome
Accession NZ_AP024871
Organism Vibrio gallicus strain CIP 107863

Toxin (Protein)


Gene name hipA Uniprot ID A0A1B9PSC6
Locus tag OCU28_RS08800 Protein ID WP_017107446.1
Coordinates 1897203..1898522 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1B9PSB5
Locus tag OCU28_RS08795 Protein ID WP_017107445.1
Coordinates 1896955..1897203 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU28_RS08780 1894140..1894334 - 195 WP_261815833.1 hypothetical protein -
OCU28_RS08785 1894563..1895249 - 687 WP_261815834.1 Mobile element protein -
OCU28_RS08790 1895450..1896436 - 987 WP_261815835.1 transposase -
OCU28_RS08795 1896955..1897203 + 249 WP_017107445.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OCU28_RS08800 1897203..1898522 + 1320 WP_017107446.1 type II toxin-antitoxin system HipA family toxin Toxin
OCU28_RS08805 1899008..1899442 + 435 WP_261815836.1 DUF411 domain-containing protein -
OCU28_RS08810 1899869..1900681 + 813 WP_261815837.1 RecX family transcriptional regulator -
OCU28_RS08815 1900917..1901261 + 345 WP_261815838.1 RidA family protein -
OCU28_RS08820 1901436..1902530 - 1095 WP_261815839.1 polysaccharide lyase family 7 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-63)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49556.88 Da        Isoelectric Point: 6.2809

>T39782 WP_017107446.1 NZ_AP024871:1897203-1898522 [Vibrio gallicus]
MQELLAYMNGELVGRLQKQSNGAHSFQYDPDWINNRKARPISLSLKLQIAPIKSDAVINYFDNLLPDAPKVRERIVARYK
ASSKQPFDLLKEVGKDSVGAIALLPPEQPYNEDKINYETLNEEKLENVLLAYKSDIPLGMLEEEEDFRISVAGAQEKTAL
LRSNDQWCIPKGNTPTTHIIKLPIGEIQQAHATLDLTDSVENEYLCIELARELGFEVPNVEIIHTEKVKALAVERFDRRW
NKDKTNLLRLPQEDICQVFGKPSSIKYESQGGPGIAEIMELLMGSSNALEDQYNFMKFQVFQWAIGATDGHAKNFSIFIE
KGGSYKLTPFYDILSAYVVLGGKGLNIRKLKLAMGIKATRGKKYEINKIYARHFLDTATSVGFSKEKMQQILDDIQVELP
QAIERLKARLPDSFPEEVSTAIFDNSLKMVKKLGINSGQ

Download         Length: 1320 bp

>T39782 NZ_AP024871:1897203-1898522 [Vibrio gallicus]
ATGCAAGAACTACTAGCTTATATGAATGGAGAGCTTGTCGGCAGATTACAAAAACAATCGAATGGTGCTCATTCTTTCCA
GTATGATCCAGACTGGATAAATAACAGAAAAGCCCGCCCCATATCTTTATCATTAAAGTTGCAAATAGCACCAATAAAAT
CAGATGCAGTTATTAATTACTTTGATAACCTTTTGCCTGATGCTCCAAAAGTTAGAGAAAGAATAGTTGCTAGATATAAA
GCCTCTTCTAAGCAACCATTTGACCTTTTAAAAGAGGTAGGTAAAGACAGTGTTGGTGCAATAGCCTTATTACCTCCTGA
GCAACCTTATAATGAAGATAAGATCAATTATGAGACGCTAAATGAAGAAAAGCTTGAAAATGTTCTTCTCGCATACAAAT
CAGATATACCCTTAGGGATGCTTGAAGAAGAGGAAGACTTCAGAATATCAGTGGCGGGCGCACAAGAAAAAACGGCTCTT
CTTCGCTCCAACGACCAATGGTGCATACCGAAAGGCAATACACCAACTACTCATATTATCAAGTTACCTATTGGAGAAAT
ACAGCAAGCTCATGCAACGTTAGATCTAACAGATAGCGTTGAAAATGAATACCTTTGTATTGAGTTGGCTAGAGAGCTTG
GTTTCGAAGTGCCTAATGTTGAGATTATCCATACTGAAAAAGTCAAAGCACTAGCAGTAGAACGTTTCGATAGACGCTGG
AACAAAGATAAAACAAATTTATTGCGATTACCTCAAGAGGATATTTGCCAAGTTTTCGGAAAACCTTCATCTATAAAGTA
TGAGTCTCAAGGTGGTCCTGGTATCGCTGAAATAATGGAGCTTTTGATGGGGTCGAGTAACGCACTAGAAGACCAATACA
ACTTCATGAAGTTCCAAGTTTTCCAGTGGGCAATTGGCGCTACAGATGGACATGCTAAGAACTTTTCCATTTTTATTGAA
AAAGGAGGAAGCTATAAGCTTACCCCTTTTTATGACATTCTATCTGCTTATGTTGTCCTTGGAGGAAAAGGATTAAATAT
AAGAAAGCTAAAGTTAGCTATGGGGATAAAAGCAACTCGTGGTAAGAAGTATGAAATAAATAAAATCTACGCTCGTCACT
TCTTAGATACAGCCACATCTGTAGGATTTAGCAAAGAAAAGATGCAACAAATCTTAGACGATATCCAAGTTGAGCTTCCT
CAAGCAATTGAACGACTAAAAGCTAGACTTCCAGATAGCTTTCCTGAAGAAGTTTCGACAGCTATATTCGATAATTCTCT
AAAAATGGTAAAAAAACTAGGTATAAATTCAGGCCAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9558.88 Da        Isoelectric Point: 5.7808

>AT39782 WP_017107445.1 NZ_AP024871:1896955-1897203 [Vibrio gallicus]
MIYSPKQLADSMLLIRQKNNWSQTELAKRVGIKQSTISNFENNPNLTTLSTFFKLLQAMNLTLKLEEKSLVQHCNDNDEE
DW

Download         Length: 249 bp

>AT39782 NZ_AP024871:1896955-1897203 [Vibrio gallicus]
ATGATATATAGCCCAAAGCAACTTGCTGATAGCATGCTTCTTATAAGGCAAAAGAACAACTGGAGTCAGACTGAGCTAGC
CAAAAGAGTTGGTATAAAGCAATCAACAATATCCAACTTCGAGAACAATCCAAATCTCACTACACTCTCAACTTTTTTTA
AACTGCTCCAAGCCATGAACTTAACACTGAAGTTAGAAGAAAAGAGCCTAGTACAACATTGTAACGATAATGATGAGGAA
GACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9PSC6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9PSB5

References