Detailed information of TA system TA039778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 1454231..1454997
• Replicon: chromosome
• Accession: NZ_AP024864
• Organism: Vibrio breoganii strain CAIM 1829

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OCU35_RS06760
• Protein ID: WP_261825034.1
• Coordinates: 1454500..1454997 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OCU35_RS06755
• Protein ID: WP_102334909.1
• Coordinates: 1454231..1454503 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU35_RS06720	1449257..1450129	+	873	WP_065209863.1	fructosamine kinase family protein	-
OCU35_RS06725	1450159..1450362	+	204	WP_017030659.1	CPXCG motif-containing cysteine-rich protein	-
OCU35_RS06730	1450359..1450970	-	612	WP_261825030.1	riboflavin synthase subunit alpha	-
OCU35_RS06735	1451158..1452528	+	1371	WP_261825031.1	MATE family efflux transporter	-
OCU35_RS06740	1452555..1453412	-	858	WP_261825032.1	DNA ligase	-
OCU35_RS06745	1453649..1454026	-	378	WP_017030663.1	hypothetical protein	-
OCU35_RS06750	1454064..1454159	-	96	WP_261825033.1	DUF3265 domain-containing protein	-
OCU35_RS06755	1454231..1454503	+	273	WP_102334909.1	DUF1778 domain-containing protein	Antitoxin
OCU35_RS06760	1454500..1454997	+	498	WP_261825034.1	GNAT family N-acetyltransferase	Toxin
OCU35_RS06765	1455166..1456110	-	945	WP_102334907.1	LysR family transcriptional regulator	-
OCU35_RS06770	1456213..1457385	+	1173	WP_261825035.1	multidrug effflux MFS transporter	-
OCU35_RS06775	1457431..1457961	-	531	WP_261825036.1	GNAT family N-acetyltransferase	-
OCU35_RS06780	1457978..1458367	-	390	WP_261825037.1	hypothetical protein	-
OCU35_RS06785	1458390..1459001	-	612	WP_261825038.1	glutathione S-transferase family protein	-
OCU35_RS06790	1459060..1459527	-	468	WP_261825039.1	OsmC family protein	-
OCU35_RS06795	1459629..1459910	-	282	WP_017027259.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (85-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18557.21 Da
• Isoelectric Point: 8.8150

>T39778 WP_261825034.1 NZ_AP024864:1454500-1454997 [Vibrio breoganii]
MMNTVLLDKAKHDRNRFNCGSEALNNYLKIMASQQAKRDNTRTFVLEDDNDNSHIIGFYTLTMTPIDLKALPDKLQKKHQ
LSTSGGLIARLAVDDRYKRKGFGEWLLIDALRKLLTASDSVAFPVVVVDAKDGAKHFYEGYGFQAFQDAENKLFITIADV
RASLG

Nucleotide

• Length: 498 bp

>T39778 NZ_AP024864:1454500-1454997 [Vibrio breoganii]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCAGCGAAGCTCTCAATAATTA
CTTGAAAATAATGGCGAGTCAGCAAGCAAAGAGAGACAACACCAGAACGTTTGTTTTAGAAGATGATAACGACAACTCAC
ATATCATCGGGTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAGTTACAAAAGAAGCACCAA
TTATCTACCTCTGGTGGTCTCATTGCTCGTCTTGCTGTCGATGACCGATATAAAAGAAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCGCTCAGAAAGCTATTAACTGCAAGTGATAGCGTTGCATTCCCTGTTGTTGTCGTTGATGCCAAAGACGGTG
CAAAACATTTCTATGAGGGCTATGGCTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGTTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9696.14 Da
• Isoelectric Point: 6.2988

>AT39778 WP_102334909.1 NZ_AP024864:1454231-1454503 [Vibrio breoganii]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDSPATQNSKLKA
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT39778 NZ_AP024864:1454231-1454503 [Vibrio breoganii]
ATGGCTACTACCTTGCCTCGCATCACAGCTAGAGTTGATGTCGATACACAAGATTTACTTACTAAGGCTGCCGCGATCGC
TGGCATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAAGCAAAACAAGTCATCGAACGCGAACAAGCTT
TAAAATTGAGCCAAGCTGATGCCATGTTGCTAATGGAAGCTTTAGACAGTCCTGCAACACAGAACTCAAAACTTAAAGCT
GCCTCTGAACGATACGAAAGCAAAACTCAATGA