Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 127532..128100 Replicon chromosome
Accession NZ_AP024862
Organism Vibrio aerogenes strain LMG 19650

Toxin (Protein)


Gene name parE Uniprot ID A0A1M6AE28
Locus tag OCV29_RS18220 Protein ID WP_073605151.1
Coordinates 127792..128100 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1M6ADX2
Locus tag OCV29_RS18215 Protein ID WP_073605152.1
Coordinates 127532..127792 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV29_RS18180 123082..124371 - 1290 WP_073605156.1 MFS transporter -
OCV29_RS18185 124343..125101 - 759 WP_073605155.1 PAS domain-containing protein -
OCV29_RS18190 125232..125456 + 225 Protein_107 hypothetical protein -
OCV29_RS18195 125488..125661 + 174 WP_073605277.1 DUF1289 domain-containing protein -
OCV29_RS18200 125735..126082 - 348 WP_073605154.1 type II toxin-antitoxin system RelE/ParE family toxin -
OCV29_RS18205 126075..126332 - 258 WP_073605153.1 prevent-host-death protein -
OCV29_RS18210 126483..126995 - 513 WP_084193447.1 Fic family protein -
OCV29_RS18215 127532..127792 + 261 WP_073605152.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCV29_RS18220 127792..128100 + 309 WP_073605151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCV29_RS18225 128120..128434 + 315 WP_073605150.1 DUF2778 domain-containing protein -
OCV29_RS18230 128431..128769 + 339 WP_073605149.1 hypothetical protein -
OCV29_RS18235 129049..129309 - 261 WP_139281657.1 hypothetical protein -
OCV29_RS18240 129448..129645 - 198 WP_073605147.1 hypothetical protein -
OCV29_RS18245 130004..132418 - 2415 WP_073605146.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11611.23 Da        Isoelectric Point: 8.5683

>T39776 WP_073605151.1 NZ_AP024862:127792-128100 [Vibrio aerogenes]
MPAYHLTPDAQADLIEIRRYTIQEWGTNQSQSYLSELRQAISLLAESPSLGKHRTDVGTGVLSFPHGSHVIYYIKHSSHI
VVFAVLHQRMLPSHHLTQRNII

Download         Length: 309 bp

>T39776 NZ_AP024862:127792-128100 [Vibrio aerogenes]
ATGCCAGCTTATCATCTCACTCCGGATGCCCAGGCTGATTTAATAGAGATACGCCGGTACACAATACAAGAATGGGGAAC
AAACCAGTCTCAGAGTTATCTTTCTGAATTGCGTCAAGCCATTAGTTTACTTGCGGAATCACCTTCTCTGGGAAAGCACA
GAACTGATGTTGGAACTGGCGTATTAAGTTTTCCTCATGGTAGTCACGTCATTTATTATATTAAACACAGCAGTCACATC
GTAGTATTTGCAGTGCTGCACCAGCGAATGCTTCCATCACATCATTTAACTCAAAGAAATATCATTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9367.65 Da        Isoelectric Point: 4.5388

>AT39776 WP_073605152.1 NZ_AP024862:127532-127792 [Vibrio aerogenes]
MNILSANEAKTHFGDMLLKAQRAPVQINRNGKPVAVVMSAEDYQSIEAMKLQLLQARASQAKADIAAGDLIDGETFFDEL
EAGKFD

Download         Length: 261 bp

>AT39776 NZ_AP024862:127532-127792 [Vibrio aerogenes]
ATGAATATACTCTCAGCAAACGAAGCCAAAACCCATTTTGGTGACATGTTGTTAAAAGCACAACGAGCCCCAGTTCAAAT
CAACAGAAATGGTAAACCGGTCGCGGTTGTGATGTCCGCCGAAGATTATCAGAGTATTGAAGCCATGAAACTACAGCTAT
TGCAGGCAAGAGCATCACAAGCAAAAGCAGATATCGCTGCCGGTGATCTCATCGATGGTGAAACTTTTTTTGATGAACTG
GAAGCAGGTAAATTCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M6AE28

Antitoxin

Source ID Structure
AlphaFold DB A0A1M6ADX2

References