Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 3429460..3430019 Replicon chromosome
Accession NZ_AP024861
Organism Vibrio aerogenes strain LMG 19650

Toxin (Protein)


Gene name relE Uniprot ID A0A1M6FJ05
Locus tag OCV29_RS15145 Protein ID WP_073606213.1
Coordinates 3429741..3430019 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1M6FIZ0
Locus tag OCV29_RS15140 Protein ID WP_073606214.1
Coordinates 3429460..3429744 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV29_RS15115 3424721..3425656 - 936 WP_073602679.1 biotin-dependent carboxyltransferase family protein -
OCV29_RS15120 3425653..3426357 - 705 WP_073602680.1 5-oxoprolinase subunit PxpB -
OCV29_RS15125 3426354..3427085 - 732 WP_073602709.1 5-oxoprolinase subunit PxpA -
OCV29_RS15130 3427281..3428165 - 885 WP_261887337.1 HEPN domain-containing protein -
OCV29_RS15135 3428613..3429053 - 441 WP_073606215.1 GFA family protein -
OCV29_RS15140 3429460..3429744 + 285 WP_073606214.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OCV29_RS15145 3429741..3430019 + 279 WP_073606213.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
OCV29_RS15150 3430171..3430444 + 274 Protein_2963 DUF1778 domain-containing protein -
OCV29_RS15155 3430441..3430521 + 81 Protein_2964 GNAT family N-acetyltransferase -
OCV29_RS15160 3430529..3431413 - 885 WP_261887338.1 HEPN domain-containing protein -
OCV29_RS15165 3431813..3432304 - 492 WP_073606177.1 GFA family protein -
OCV29_RS15170 3432492..3433124 + 633 WP_073606178.1 LysE family translocator -
OCV29_RS15175 3433344..3433604 + 261 WP_073606179.1 hypothetical protein -
OCV29_RS15180 3433601..3433927 - 327 WP_139281727.1 transposase -
OCV29_RS15185 3434296..3434790 - 495 WP_073606180.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10812.51 Da        Isoelectric Point: 4.3430

>T39775 WP_073606213.1 NZ_AP024861:3429741-3430019 [Vibrio aerogenes]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEEKAENLTGQPLMGVQRDGIRGRLLIIPEISMIISYCVEGDIIRIM
RVLHQKQKFPMD

Download         Length: 279 bp

>T39775 NZ_AP024861:3429741-3430019 [Vibrio aerogenes]
ATGATTTTATGGGAAGAAGAGTCACTGAATGATCGCGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCAGC
AGAGAAAACTGACAACCTCATTGAAGAAAAAGCAGAAAACCTGACCGGGCAGCCTCTCATGGGCGTACAGCGAGATGGCA
TTCGTGGACGCTTACTCATTATTCCTGAAATTTCGATGATCATTTCCTATTGTGTCGAAGGCGATATCATCCGAATTATG
CGTGTGCTCCACCAGAAACAAAAATTCCCTATGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10963.32 Da        Isoelectric Point: 10.0201

>AT39775 WP_073606214.1 NZ_AP024861:3429460-3429744 [Vibrio aerogenes]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKLDSGKAVFTEHQTAKSR
MEARKARIRNRGKQ

Download         Length: 285 bp

>AT39775 NZ_AP024861:3429460-3429744 [Vibrio aerogenes]
ATGGACACCAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGTCTGGCTCAACAAATGGCTGAGAGTCAGGGTCGCAC
ACTGAGTGATGCTTGCCGTGAGCTGACTGAGCAACTCGCTGAGCAGCAAAGAAAAACATTATCTCACGATGCATGGCTCA
CTGAACAAGTCAACCTGGCATTTGAGAAGTTAGACTCCGGAAAAGCGGTTTTCACTGAACACCAAACGGCTAAATCCCGA
ATGGAAGCGCGCAAAGCCAGAATCCGTAACCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M6FJ05

Antitoxin

Source ID Structure
AlphaFold DB A0A1M6FIZ0

References