Detailed information of TA system TA039772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2289001..2289673
• Replicon: chromosome
• Accession: NZ_AP024861
• Organism: Vibrio aerogenes strain LMG 19650

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1M5Z4D6
• Locus tag: OCV29_RS10145
• Protein ID: WP_073603944.1
• Coordinates: 2289299..2289673 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: OCV29_RS10140
• Protein ID: WP_245796855.1
• Coordinates: 2289001..2289309 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV29_RS10120	2284598..2285638	+	1041	WP_261887394.1	methionine synthase	-
OCV29_RS10125	2285741..2285992	-	252	WP_073603947.1	hypothetical protein	-
OCV29_RS10130	2286127..2287143	+	1017	WP_245796857.1	helix-turn-helix transcriptional regulator	-
OCV29_RS10135	2287140..2288822	-	1683	WP_073603946.1	2-isopropylmalate synthase	-
OCV29_RS10140	2289001..2289309	-	309	WP_245796855.1	DNA-binding transcriptional regulator	Antitoxin
OCV29_RS10145	2289299..2289673	-	375	WP_073603944.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV29_RS10150	2289883..2291478	-	1596	WP_073603943.1	ABC-F family ATPase	-
OCV29_RS10155	2291646..2291948	+	303	WP_073603942.1	NIPSNAP family protein	-
OCV29_RS10160	2292083..2293003	+	921	WP_073603941.1	GNAT family N-acetyltransferase	-
OCV29_RS10165	2293034..2293197	-	164	Protein_1985	glyoxalase/bleomycin resistance/dioxygenase family protein	-
OCV29_RS10170	2293223..2294152	-	930	WP_084193321.1	isoaspartyl peptidase/L-asparaginase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-120)

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-100)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13889.03 Da
• Isoelectric Point: 8.5253

>T39772 WP_073603944.1 NZ_AP024861:c2289673-2289299 [Vibrio aerogenes]
MRIFKTRAFHKWAIKTGLNDLALLTAVHEIEYGLVDADLGGHVIKKRVSLAQRGKRSGARTVLVYQAHHQAFFIYGFAKN
ARSNILPDELKALKQLAIELLNYSEHALGLAIEHGALIEVEDDE

Nucleotide

• Length: 375 bp

>T39772 NZ_AP024861:c2289673-2289299 [Vibrio aerogenes]
ATGAGGATATTCAAAACCAGAGCTTTTCACAAATGGGCAATCAAAACCGGACTCAATGATCTGGCGCTATTGACGGCAGT
CCATGAGATTGAATATGGTCTTGTCGATGCTGATTTGGGCGGGCATGTGATTAAAAAGCGTGTCTCGCTTGCTCAACGAG
GAAAGCGTAGTGGCGCCAGAACTGTTTTGGTGTATCAAGCTCATCATCAGGCATTTTTTATCTATGGTTTTGCCAAAAAT
GCCCGCTCGAATATTCTTCCTGATGAGTTAAAAGCGCTAAAGCAATTAGCCATTGAGCTCCTGAACTATTCTGAACACGC
TCTAGGCCTTGCTATTGAGCATGGCGCGTTAATTGAGGTTGAAGATGATGAATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11248.11 Da
• Isoelectric Point: 10.4329

>AT39772 WP_245796855.1 NZ_AP024861:c2289309-2289001 [Vibrio aerogenes]
MMNKSILETVHHTAHDLHSAGVMKDTTMREFDTLCLPLVKTFSAKEIKAIRTQNRASQGVFAAYLNISKSTVQKWEQGQK
KPNGPSLKLLNLVADKGLGVLA

Nucleotide

• Length: 309 bp

>AT39772 NZ_AP024861:c2289309-2289001 [Vibrio aerogenes]
ATGATGAATAAATCTATCTTAGAAACTGTGCATCATACTGCGCATGATCTACATTCAGCAGGTGTCATGAAAGACACGAC
GATGCGGGAATTCGATACCCTTTGCCTGCCGCTGGTTAAAACGTTTTCTGCTAAAGAAATCAAAGCAATTCGTACCCAAA
ACCGTGCCAGTCAAGGTGTTTTTGCTGCCTATCTGAATATCAGCAAATCCACCGTGCAGAAATGGGAACAAGGTCAGAAG
AAACCGAATGGTCCATCGTTGAAATTGTTAAATCTGGTGGCGGATAAGGGATTAGGTGTACTAGCGTAA

Structures

Toxin

• AlphaFold DB: A0A1M5Z4D6