Detailed information of TA system TA039768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /ElaA-DUF1778
• Location: 381835..382604
• Replicon: chromosome
• Accession: NZ_AP024853
• Organism: Photobacterium swingsii strain CECT 7576

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0J8VE57
• Locus tag: OCU77_RS19085
• Protein ID: WP_048897890.1
• Coordinates: 382107..382604 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OCU77_RS19080
• Protein ID: WP_048897889.1
• Coordinates: 381835..382110 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU77_RS19050	377240..377563	-	324	WP_239685880.1	polymer-forming cytoskeletal protein	-
OCU77_RS19055	377578..378528	-	951	WP_048897886.1	M23 family metallopeptidase	-
OCU77_RS19060	379481..379965	+	485	Protein_336	phage protein	-
OCU77_RS19065	380089..380580	-	492	WP_048897887.1	hypothetical protein	-
OCU77_RS19070	380755..381345	-	591	WP_048897888.1	hypothetical protein	-
OCU77_RS19075	381459..381602	-	144	WP_160314699.1	hypothetical protein	-
OCU77_RS19080	381835..382110	+	276	WP_048897889.1	DUF1778 domain-containing protein	Antitoxin
OCU77_RS19085	382107..382604	+	498	WP_048897890.1	GNAT family N-acetyltransferase	Toxin
OCU77_RS19090	382976..383224	-	249	WP_048897891.1	DUF3297 family protein	-
OCU77_RS19095	383818..384693	+	876	WP_048897892.1	RNA polymerase sigma factor RpoS	-
OCU77_RS19100	384833..385381	+	549	WP_048897893.1	DUF1439 domain-containing protein	-
OCU77_RS19105	385474..385770	-	297	WP_048897894.1	hypothetical protein	-
OCU77_RS19110	385955..387109	-	1155	WP_048897895.1	chromate efflux transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (84-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-90)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18671.45 Da
• Isoelectric Point: 7.8822

>T39768 WP_048897890.1 NZ_AP024853:382107-382604 [Photobacterium swingsii]
MKTVQLNKNKHDRHRFDCGIDALNNYLKIMASQQAKKDNTRTFVLEDTNCAEHVVGYYTLTMTPIDLTLLPLKLLKKHQN
ASSGGLIARLAVDQRYKGNGYGEWLLIDALKKLLMASETVAFPLVIVDAKDGAEYFYEKYGFTAFQDTENKLFITISDVR
ASISD

Nucleotide

• Length: 498 bp

>T39768 NZ_AP024853:382107-382604 [Photobacterium swingsii]
ATGAAGACGGTACAGTTAAACAAAAACAAACACGACCGTCATCGCTTTGATTGTGGTATTGATGCTCTAAACAACTATCT
GAAAATAATGGCTAGTCAGCAGGCCAAAAAAGACAACACGCGTACTTTTGTTCTTGAAGATACTAATTGCGCAGAACATG
TTGTTGGCTACTACACGCTAACTATGACCCCCATTGATTTGACATTATTACCACTCAAATTATTAAAGAAACATCAGAAT
GCAAGCTCTGGTGGGCTAATTGCACGACTTGCTGTGGATCAACGATACAAAGGGAACGGCTATGGCGAATGGTTACTGAT
TGACGCATTGAAAAAGCTACTAATGGCAAGTGAAACTGTCGCTTTTCCTCTTGTTATCGTCGACGCAAAAGATGGTGCCG
AATACTTTTACGAAAAATACGGTTTCACTGCTTTTCAAGATACAGAAAACAAACTTTTTATAACCATCTCTGATGTCCGA
GCTAGCATTAGCGACTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10089.72 Da
• Isoelectric Point: 9.8109

>AT39768 WP_048897889.1 NZ_AP024853:381835-382110 [Photobacterium swingsii]
MATALPRITARVDIDTQELLSQAAAIAGMSSINSFVLSAAVEKAKQIMERERALKLSQRDAMMLMDALDEPAKPNLRLKQ
AADRYKDKTQQ

Nucleotide

• Length: 276 bp

>AT39768 NZ_AP024853:381835-382110 [Photobacterium swingsii]
ATGGCTACAGCTCTACCTCGTATCACTGCTCGTGTAGACATCGATACTCAAGAATTACTATCGCAGGCTGCTGCTATTGC
CGGTATGTCTAGTATTAATTCCTTTGTTCTAAGTGCCGCAGTTGAAAAAGCAAAACAGATTATGGAACGTGAACGAGCAC
TCAAGCTCAGCCAACGCGATGCAATGATGCTTATGGATGCACTTGATGAACCTGCAAAACCTAACCTGCGTTTAAAGCAA
GCAGCAGATCGTTACAAGGATAAGACACAGCAATGA

Structures

Toxin

• AlphaFold DB: A0A0J8VE57