Detailed information of TA system TA039765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1576993..1577540
• Replicon: chromosome
• Accession: NZ_AP024850
• Organism: Photobacterium sanguinicancri strain CECT 7579

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCU87_RS07530
• Protein ID: WP_261858150.1
• Coordinates: 1577238..1577540 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A135ZK88
• Locus tag: OCU87_RS07525
• Protein ID: WP_062691086.1
• Coordinates: 1576993..1577250 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU87_RS07515	1572146..1572595	-	450	WP_261858149.1	TerB family tellurite resistance protein	-
OCU87_RS07520	1572926..1576765	+	3840	WP_261858355.1	ATP-dependent RNA helicase HrpA	-
OCU87_RS07525	1576993..1577250	+	258	WP_062691086.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCU87_RS07530	1577238..1577540	+	303	WP_261858150.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCU87_RS07535	1577666..1578970	-	1305	WP_261858356.1	inosine/guanosine kinase	-
OCU87_RS07540	1579207..1579902	-	696	WP_062691084.1	DUF2786 domain-containing protein	-
OCU87_RS07545	1580081..1581052	+	972	WP_062691083.1	hypothetical protein	-
OCU87_RS07550	1581129..1581572	-	444	WP_062691082.1	DUF411 domain-containing protein	-
OCU87_RS07555	1581726..1582082	-	357	WP_062691081.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11663.60 Da
• Isoelectric Point: 4.8779

>T39765 WP_261858150.1 NZ_AP024850:1577238-1577540 [Photobacterium sanguinicancri]
MAELIWTEPALSDLNDIAEYIALENVVAAKQLVQTIFSKVERLEAFPESGRIPPELEYLNYREVVVNPCRIFYKQGGDKV
FILFVMRVERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T39765 NZ_AP024850:1577238-1577540 [Photobacterium sanguinicancri]
ATGGCTGAATTAATCTGGACTGAACCAGCGTTATCCGATCTCAATGATATAGCTGAATACATCGCACTTGAAAACGTCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTCTCTAAAGTTGAGCGTCTAGAGGCTTTTCCTGAGTCTGGGCGTATTCCAC
CTGAACTAGAATATCTAAATTACCGTGAAGTTGTCGTTAATCCATGCCGTATTTTCTATAAGCAAGGCGGTGACAAAGTA
TTTATTCTGTTTGTTATGCGCGTAGAAAGAGATTTGCGAAAGTTCCTGTTGAGTAAGCAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9650.11 Da
• Isoelectric Point: 6.2283

>AT39765 WP_062691086.1 NZ_AP024850:1576993-1577250 [Photobacterium sanguinicancri]
MKVELVTSLKRQATKILSELHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVTHEEAKDKM
SKWLN

Nucleotide

• Length: 258 bp

>AT39765 NZ_AP024850:1576993-1577250 [Photobacterium sanguinicancri]
ATGAAAGTAGAACTAGTCACCTCGCTGAAGCGTCAAGCAACTAAGATCCTCTCCGAGCTCCACGACACTAAAGAGCCAGT
ATTAATTACCGAACACGGTAAACCATCTGCATATTTAGTCGATGTGGATGATTACGAGTTTATGCAAAACCGTTTGGCAA
TTCTTGAGGGTATTGCGCGAGGGGAACGTGCGTTAGCAGACGGTAAAGTTGTTACTCACGAAGAAGCCAAGGACAAAATG
TCAAAATGGCTGAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A135ZK88