Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4738487..4739278 Replicon chromosome
Accession NZ_AP024847
Organism Serratia marcescens strain 2020-O-9

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LDN81_RS22890 Protein ID WP_041036757.1
Coordinates 4738487..4738864 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LDN81_RS22895 Protein ID WP_041036759.1
Coordinates 4738916..4739278 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDN81_RS22855 (SMGES_45310) 4733973..4734209 - 237 WP_013098810.1 hypothetical protein -
LDN81_RS22860 (SMGES_45320) 4734298..4734951 + 654 WP_072072161.1 phage repressor protein CI -
LDN81_RS22865 (SMGES_45330) 4734944..4735378 + 435 WP_044157615.1 hypothetical protein -
LDN81_RS22870 (SMGES_45350) 4735566..4736651 + 1086 WP_013098812.1 tyrosine-type recombinase/integrase -
LDN81_RS22875 (SMGES_45360) 4736840..4737685 - 846 WP_041038127.1 DUF4942 domain-containing protein -
LDN81_RS22880 (SMGES_45370) 4737766..4737969 - 204 WP_041036753.1 DUF957 domain-containing protein -
LDN81_RS22885 (SMGES_45380) 4737999..4738490 - 492 WP_041036755.1 DUF5983 family protein -
LDN81_RS22890 (SMGES_45390) 4738487..4738864 - 378 WP_041036757.1 TA system toxin CbtA family protein Toxin
LDN81_RS22895 (SMGES_45400) 4738916..4739278 - 363 WP_041036759.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LDN81_RS22900 (SMGES_45410) 4739302..4739523 - 222 WP_041036761.1 DUF987 domain-containing protein -
LDN81_RS22905 (SMGES_45420) 4739538..4740017 - 480 WP_041036763.1 DNA repair protein RadC -
LDN81_RS22910 (SMGES_45430) 4740029..4740508 - 480 WP_041036765.1 antirestriction protein -
LDN81_RS22915 (SMGES_45450) 4740779..4741597 - 819 WP_041036766.1 DUF932 domain-containing protein -
LDN81_RS22920 (SMGES_45460) 4741687..4742625 - 939 WP_080335451.1 hypothetical protein -
LDN81_RS22925 (SMGES_45470) 4742691..4743101 - 411 WP_041038131.1 hypothetical protein -
LDN81_RS22930 (SMGES_45480) 4743215..4743430 - 216 WP_041036768.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4698997..4744300 45303


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13901.82 Da        Isoelectric Point: 5.0875

>T39763 WP_041036757.1 NZ_AP024847:c4738864-4738487 [Serratia marcescens]
MQTQPLSSTQEASPRPTPVEIWQQLLIYLLEQHYGLSLNDTPFGTDGVIPEHIDAGISLCDAVNFIVEKYDLVRIDRRSV
SAETQSLLISSIDILRARKACGLMTRNGYRMVTDITTGKYSGATQ

Download         Length: 378 bp

>T39763 NZ_AP024847:c4738864-4738487 [Serratia marcescens]
ATGCAAACCCAACCACTATCCTCCACGCAGGAGGCTTCGCCACGTCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAT
ATATCTGCTGGAACAGCATTATGGCCTTTCACTTAACGACACTCCGTTTGGCACCGATGGTGTCATTCCGGAACATATTG
ACGCAGGTATTTCACTGTGCGACGCGGTGAATTTCATCGTCGAAAAGTACGATCTTGTCCGTATCGATCGTCGCAGTGTC
AGTGCAGAAACACAGTCCCTGCTCATCAGCAGTATTGATATACTCCGCGCCCGTAAGGCCTGTGGATTGATGACGCGCAA
CGGCTACAGAATGGTAACCGATATCACCACCGGCAAATACAGCGGAGCGACTCAATGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13383.19 Da        Isoelectric Point: 6.4791

>AT39763 WP_041036759.1 NZ_AP024847:c4739278-4738916 [Serratia marcescens]
MSNKIPAENHDITDPWWGLKRSITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPVLLRQLELMLVSGELS
PRHQHCVTLYAKGLTCEADSLGSHGYMYVAIYPTPSEATA

Download         Length: 363 bp

>AT39763 NZ_AP024847:c4739278-4738916 [Serratia marcescens]
TTGTCGAATAAAATACCGGCAGAAAACCACGATATCACTGACCCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCTGCACTATCTCGCTGACCGCGCCAGTATCACCGGGCAGTTCAGCGACG
CGGATTTACGCCATCTCGACCAGGCATTTCCGGTACTGCTCAGACAACTGGAGTTAATGCTGGTTTCCGGTGAGCTCAGT
CCCCGCCATCAGCACTGTGTCACGTTATACGCAAAAGGGCTGACCTGCGAGGCGGACAGCCTCGGCTCGCATGGATACAT
GTACGTAGCGATTTACCCGACACCATCTGAAGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References