Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4444990..4445659 Replicon chromosome
Accession NZ_AP024847
Organism Serratia marcescens strain 2020-O-9

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LDN81_RS21470 Protein ID WP_041036558.1
Coordinates 4444990..4445412 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag LDN81_RS21475 Protein ID WP_004931679.1
Coordinates 4445393..4445659 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDN81_RS21450 (SMGES_42530) 4440879..4441397 + 519 WP_033635825.1 flavodoxin FldB -
LDN81_RS21455 (SMGES_42540) 4441435..4442799 - 1365 WP_041036554.1 cell envelope integrity protein CreD -
LDN81_RS21460 (SMGES_42550) 4442880..4444298 - 1419 WP_033654070.1 two-component system sensor histidine kinase CreC -
LDN81_RS21465 (SMGES_42560) 4444295..4444990 - 696 WP_041036556.1 two-component system response regulator CreB -
LDN81_RS21470 (SMGES_42570) 4444990..4445412 - 423 WP_041036558.1 protein YgfX Toxin
LDN81_RS21475 (SMGES_42580) 4445393..4445659 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
LDN81_RS21480 (SMGES_42600) 4445980..4446972 + 993 WP_041036561.1 tRNA-modifying protein YgfZ -
LDN81_RS21485 (SMGES_42610) 4447011..4447508 - 498 WP_033649451.1 DUF2165 domain-containing protein -
LDN81_RS21490 (SMGES_42620) 4447659..4448333 - 675 WP_038871224.1 hemolysin III family protein -
LDN81_RS21495 (SMGES_42630) 4448517..4449125 + 609 WP_025304127.1 HD domain-containing protein -
LDN81_RS21500 (SMGES_42640) 4449158..4450084 - 927 WP_033635835.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4438934..4504972 66038


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16441.56 Da        Isoelectric Point: 10.8114

>T39762 WP_041036558.1 NZ_AP024847:c4445412-4444990 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLAHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Download         Length: 423 bp

>T39762 NZ_AP024847:c4445412-4444990 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGGCCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT39762 WP_004931679.1 NZ_AP024847:c4445659-4445393 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT39762 NZ_AP024847:c4445659-4445393 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References