Detailed information of TA system TA039760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4045411..4046067
• Replicon: chromosome
• Accession: NZ_AP024847
• Organism: Serratia marcescens strain 2020-O-9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2V4G0W2
• Locus tag: LDN81_RS19535
• Protein ID: WP_041036282.1
• Coordinates: 4045411..4045800 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: LDN81_RS19540
• Protein ID: WP_004941563.1
• Coordinates: 4045804..4046067 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDN81_RS19520 (SMGES_38700)	4041878..4043308	+	1431	WP_041036278.1	multidrug transporter subunit MdtD	-
LDN81_RS19525 (SMGES_38710)	4043305..4044687	+	1383	WP_033635541.1	two-component system sensor histidine kinase BaeS	-
LDN81_RS19530 (SMGES_38720)	4044687..4045403	+	717	WP_033635542.1	two-component system response regulator BaeR	-
LDN81_RS19535 (SMGES_38730)	4045411..4045800	-	390	WP_041036282.1	type II toxin-antitoxin system VapC family toxin	Toxin
LDN81_RS19540 (SMGES_38740)	4045804..4046067	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LDN81_RS19545 (SMGES_38750)	4046407..4046745	+	339	WP_033648841.1	YegP family protein	-
LDN81_RS19550 (SMGES_38760)	4046926..4048278	+	1353	WP_033635545.1	tRNA 5-hydroxyuridine modification protein YegQ	-
LDN81_RS19555 (SMGES_38770)	4048745..4049650	+	906	WP_041036284.1	lipid kinase YegS	-
LDN81_RS19560 (SMGES_38780)	4049940..4050989	+	1050	WP_033635553.1	class I fructose-bisphosphate aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14309.56 Da
• Isoelectric Point: 7.8786

>T39760 WP_041036282.1 NZ_AP024847:c4045800-4045411 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T39760 NZ_AP024847:c4045800-4045411 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT39760 WP_004941563.1 NZ_AP024847:c4046067-4045804 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT39760 NZ_AP024847:c4046067-4045804 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2V4G0W2