Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 3232645..3233276 | Replicon | chromosome |
Accession | NZ_AP024847 | ||
Organism | Serratia marcescens strain 2020-O-9 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A5C7D7C3 |
Locus tag | LDN81_RS15740 | Protein ID | WP_033640020.1 |
Coordinates | 3232645..3233043 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A5C7D7A2 |
Locus tag | LDN81_RS15745 | Protein ID | WP_041035628.1 |
Coordinates | 3233043..3233276 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LDN81_RS15720 (SMGES_31120) | 3227745..3228560 | - | 816 | WP_041035622.1 | 5'-nucleotidase, lipoprotein e(P4) family | - |
LDN81_RS15725 (SMGES_31130) | 3228889..3229293 | - | 405 | WP_041035624.1 | flagellar protein FlhE | - |
LDN81_RS15730 (SMGES_31140) | 3229293..3231371 | - | 2079 | WP_033635001.1 | flagellar biosynthesis protein FlhA | - |
LDN81_RS15735 (SMGES_31150) | 3231364..3232515 | - | 1152 | WP_015378261.1 | flagellar biosynthesis protein FlhB | - |
LDN81_RS15740 (SMGES_31160) | 3232645..3233043 | - | 399 | WP_033640020.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LDN81_RS15745 (SMGES_31170) | 3233043..3233276 | - | 234 | WP_041035628.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
LDN81_RS15750 (SMGES_31180) | 3233401..3234045 | - | 645 | WP_004934858.1 | protein phosphatase CheZ | - |
LDN81_RS15755 (SMGES_31190) | 3234056..3234445 | - | 390 | WP_041035631.1 | chemotaxis response regulator CheY | - |
LDN81_RS15760 (SMGES_31200) | 3234548..3235597 | - | 1050 | WP_033635003.1 | chemotaxis response regulator protein-glutamate methylesterase | - |
LDN81_RS15765 (SMGES_31210) | 3235597..3236469 | - | 873 | WP_025159837.1 | protein-glutamate O-methyltransferase CheR | - |
LDN81_RS15770 (SMGES_31220) | 3236507..3238123 | - | 1617 | WP_033653630.1 | methyl-accepting chemotaxis protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14918.11 Da Isoelectric Point: 8.4955
>T39758 WP_033640020.1 NZ_AP024847:c3233043-3232645 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL
Download Length: 399 bp
>T39758 NZ_AP024847:c3233043-3232645 [Serratia marcescens]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCAATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAACGCGTTGAGGGTTTACGGCTGGAAAATTGGTTGTAA
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCAATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAACGCGTTGAGGGTTTACGGCTGGAAAATTGGTTGTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8871.88 Da Isoelectric Point: 4.7815
>AT39758 WP_041035628.1 NZ_AP024847:c3233276-3233043 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF
Download Length: 234 bp
>AT39758 NZ_AP024847:c3233276-3233043 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5C7D7C3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5C7D7A2 |