Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3232645..3233276 Replicon chromosome
Accession NZ_AP024847
Organism Serratia marcescens strain 2020-O-9

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag LDN81_RS15740 Protein ID WP_033640020.1
Coordinates 3232645..3233043 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag LDN81_RS15745 Protein ID WP_041035628.1
Coordinates 3233043..3233276 (-) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDN81_RS15720 (SMGES_31120) 3227745..3228560 - 816 WP_041035622.1 5'-nucleotidase, lipoprotein e(P4) family -
LDN81_RS15725 (SMGES_31130) 3228889..3229293 - 405 WP_041035624.1 flagellar protein FlhE -
LDN81_RS15730 (SMGES_31140) 3229293..3231371 - 2079 WP_033635001.1 flagellar biosynthesis protein FlhA -
LDN81_RS15735 (SMGES_31150) 3231364..3232515 - 1152 WP_015378261.1 flagellar biosynthesis protein FlhB -
LDN81_RS15740 (SMGES_31160) 3232645..3233043 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
LDN81_RS15745 (SMGES_31170) 3233043..3233276 - 234 WP_041035628.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LDN81_RS15750 (SMGES_31180) 3233401..3234045 - 645 WP_004934858.1 protein phosphatase CheZ -
LDN81_RS15755 (SMGES_31190) 3234056..3234445 - 390 WP_041035631.1 chemotaxis response regulator CheY -
LDN81_RS15760 (SMGES_31200) 3234548..3235597 - 1050 WP_033635003.1 chemotaxis response regulator protein-glutamate methylesterase -
LDN81_RS15765 (SMGES_31210) 3235597..3236469 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
LDN81_RS15770 (SMGES_31220) 3236507..3238123 - 1617 WP_033653630.1 methyl-accepting chemotaxis protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-124)

Antitoxin

(7-45)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T39758 WP_033640020.1 NZ_AP024847:c3233043-3232645 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T39758 NZ_AP024847:c3233043-3232645 [Serratia marcescens]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCAATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAACGCGTTGAGGGTTTACGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT39758 WP_041035628.1 NZ_AP024847:c3233276-3233043 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT39758 NZ_AP024847:c3233276-3233043 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3


Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References