Detailed information of TA system TA039749

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1791840..1792365
• Replicon: chromosome
• Accession: NZ_AP024847
• Organism: Serratia marcescens strain 2020-O-9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDN81_RS08685
• Protein ID: WP_041034302.1
• Coordinates: 1791840..1792124 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: LDN81_RS08690
• Protein ID: WP_004928423.1
• Coordinates: 1792114..1792365 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDN81_RS08660 (SMGES_17010)	1787100..1788233	+	1134	WP_033637812.1	putrescine ABC transporter ATP-binding subunit PotG	-
LDN81_RS08665 (SMGES_17020)	1788258..1789220	+	963	WP_033646669.1	putrescine ABC transporter permease PotH	-
LDN81_RS08670 (SMGES_17030)	1789217..1790062	+	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
LDN81_RS08675 (SMGES_17040)	1790167..1790646	+	480	WP_048321404.1	YbjO family protein	-
LDN81_RS08680 (SMGES_17050)	1790716..1791843	+	1128	WP_041034300.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
LDN81_RS08685 (SMGES_17060)	1791840..1792124	-	285	WP_041034302.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDN81_RS08690 (SMGES_17070)	1792114..1792365	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
LDN81_RS08695 (SMGES_17080)	1792467..1793201	-	735	WP_041034305.1	arginine ABC transporter substrate-binding protein	-
LDN81_RS08700 (SMGES_17090)	1793401..1794069	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
LDN81_RS08705 (SMGES_17100)	1794069..1794785	-	717	WP_033637818.1	arginine ABC transporter permease ArtQ	-
LDN81_RS08710 (SMGES_17110)	1794795..1795526	-	732	WP_033637819.1	arginine ABC transporter substrate-binding protein	-
LDN81_RS08715 (SMGES_17120)	1795559..1796287	-	729	WP_038884338.1	arginine ABC transporter ATP-binding protein ArtP	-
LDN81_RS08720 (SMGES_17130)	1796552..1797094	-	543	WP_033637821.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10798.92 Da
• Isoelectric Point: 10.5850

>T39749 WP_041034302.1 NZ_AP024847:c1792124-1791840 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
REHSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T39749 NZ_AP024847:c1792124-1791840 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCAGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACATTCAGCGGCTTATACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT39749 WP_004928423.1 NZ_AP024847:c1792365-1792114 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT39749 NZ_AP024847:c1792365-1792114 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1