Detailed information of TA system TA039747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1527528..1528095
• Replicon: chromosome
• Accession: NZ_AP024847
• Organism: Serratia marcescens strain 2020-O-9

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LDN81_RS07450
• Protein ID: WP_033637605.1
• Coordinates: 1527528..1527833 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A5C7DM00
• Locus tag: LDN81_RS07455
• Protein ID: WP_033637606.1
• Coordinates: 1527835..1528095 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDN81_RS07415 (SMGES_14480)	1523176..1524252	+	1077	WP_041034054.1	urea ABC transporter permease subunit UrtC	-
LDN81_RS07420 (SMGES_14490)	1524249..1525055	+	807	WP_015377102.1	urea ABC transporter ATP-binding protein UrtD	-
LDN81_RS07425 (SMGES_14500)	1525068..1525766	+	699	WP_041034056.1	urea ABC transporter ATP-binding subunit UrtE	-
LDN81_RS07430 (SMGES_14510)	1525774..1526109	-	336	WP_223915741.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LDN81_RS07435 (SMGES_14520)	1526057..1526320	-	264	WP_033646967.1	type II toxin-antitoxin system ParD family antitoxin	-
LDN81_RS07440 (SMGES_14530)	1526456..1526968	+	513	WP_041034057.1	DUF2165 family protein	-
LDN81_RS07445 (SMGES_14540)	1526991..1527503	-	513	WP_041034059.1	GNAT family N-acetyltransferase	-
LDN81_RS07450 (SMGES_14550)	1527528..1527833	-	306	WP_033637605.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDN81_RS07455 (SMGES_14560)	1527835..1528095	-	261	WP_033637606.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDN81_RS07460 (SMGES_14570)	1528164..1529399	-	1236	WP_041034061.1	FAD-dependent oxidoreductase	-
LDN81_RS07465 (SMGES_14580)	1529741..1530610	+	870	WP_033637609.1	LysR substrate-binding domain-containing protein	-
LDN81_RS07470 (SMGES_14590)	1530607..1531452	-	846	WP_041034063.1	3-mercaptopyruvate sulfurtransferase	-
LDN81_RS07475 (SMGES_14600)	1531555..1531977	+	423	WP_033646950.1	NUDIX hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-65)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11957.71 Da
• Isoelectric Point: 9.5902

>T39747 WP_033637605.1 NZ_AP024847:c1527833-1527528 [Serratia marcescens]
MPAFRLTPQAQQDLLAIRHFTVEHWGQTQSRRYLEQLREIMHHLADMPEAGKAHFHDLGEEIRSFPYASHRIYYRSRPAG
ITVLAILHQAMVPHRHLEQRL

Nucleotide

• Length: 306 bp

>T39747 NZ_AP024847:c1527833-1527528 [Serratia marcescens]
ATGCCCGCGTTTCGCCTCACCCCGCAAGCCCAACAAGATCTGCTGGCTATTCGCCATTTCACCGTCGAGCACTGGGGCCA
AACGCAATCTCGCCGCTATCTTGAGCAGTTGAGAGAGATCATGCATCATCTGGCGGACATGCCGGAAGCGGGTAAAGCCC
ACTTTCACGATCTGGGTGAAGAGATACGCAGTTTTCCTTACGCCAGCCATAGGATCTACTACCGCAGCCGCCCTGCCGGC
ATCACCGTTCTTGCCATTTTGCATCAGGCGATGGTGCCCCACCGGCATCTGGAACAACGGCTGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9497.67 Da
• Isoelectric Point: 4.3193

>AT39747 WP_033637606.1 NZ_AP024847:c1528095-1527835 [Serratia marcescens]
MYALSANEAKTQFGDLLLKAQREPVQINRNGKPVAVVMSVEDYQALEDLKLRALQQKIAQATAEEDAGKAVDGDAFFNRL
LTDETD

Nucleotide

• Length: 261 bp

>AT39747 NZ_AP024847:c1528095-1527835 [Serratia marcescens]
ATGTACGCACTCAGCGCGAACGAGGCCAAAACCCAATTCGGCGATTTGCTGCTCAAGGCGCAGCGTGAGCCGGTGCAAAT
CAATCGCAACGGCAAACCGGTCGCCGTCGTCATGTCGGTAGAAGACTACCAGGCGCTGGAAGATCTCAAACTACGCGCAC
TGCAGCAAAAAATCGCGCAGGCTACCGCCGAGGAAGACGCCGGTAAGGCGGTAGACGGTGATGCCTTCTTCAACCGTCTG
CTCACCGATGAAACCGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DM00