Detailed information of TA system TA039744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 55693..56228
• Replicon: chromosome
• Accession: NZ_AP024847
• Organism: Serratia marcescens strain 2020-O-9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDN81_RS00250
• Protein ID: WP_033649525.1
• Coordinates: 55953..56228 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5C7DDR0
• Locus tag: LDN81_RS00245
• Protein ID: WP_041037283.1
• Coordinates: 55693..55953 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDN81_RS00225 (SMGES_00470)	51012..51662	+	651	WP_033636562.1	DcrB-related protein	-
LDN81_RS00230 (SMGES_00480)	51703..52308	+	606	WP_033636563.1	glutathione S-transferase	-
LDN81_RS00235 (SMGES_00490)	52378..53772	+	1395	WP_041037287.1	L-seryl-tRNA(Sec) selenium transferase	-
LDN81_RS00240 (SMGES_00500)	53769..55610	+	1842	WP_041037285.1	selenocysteine-specific translation elongation factor	-
LDN81_RS00245 (SMGES_00510)	55693..55953	+	261	WP_041037283.1	ribbon-helix-helix domain-containing protein	Antitoxin
LDN81_RS00250 (SMGES_00520)	55953..56228	+	276	WP_033649525.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDN81_RS00255 (SMGES_00530)	56240..57151	-	912	WP_041037279.1	LysR family transcriptional regulator	-
LDN81_RS00260 (SMGES_00540)	57273..57899	+	627	WP_041037277.1	LysE family translocator	-
LDN81_RS00265 (SMGES_00550)	57953..59200	-	1248	WP_041038165.1	MFS transporter	-
LDN81_RS00270 (SMGES_00560)	59418..60410	+	993	WP_041037275.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10596.34 Da
• Isoelectric Point: 10.3377

>T39744 WP_033649525.1 NZ_AP024847:55953-56228 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALVNRTAAANSVKALVAAPKALLDNSRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T39744 NZ_AP024847:55953-56228 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGTTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATTCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9653.95 Da
• Isoelectric Point: 4.5084

>AT39744 WP_041037283.1 NZ_AP024847:55693-55953 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Nucleotide

• Length: 261 bp

>AT39744 NZ_AP024847:55693-55953 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGACCG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DDR0