Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 125585..126101 Replicon chromosome
Accession NZ_AP024845
Organism Eubacterium sp. c-25

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EUBC25_RS00660 Protein ID WP_230106339.1
Coordinates 125585..125845 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag EUBC25_RS00665 Protein ID WP_230106340.1
Coordinates 125838..126101 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EUBC25_RS00630 (EUBC25_01240) 120771..121265 + 495 WP_230106334.1 HD domain-containing protein -
EUBC25_RS00640 (EUBC25_01250) 121555..122199 - 645 WP_230106335.1 ATP-binding cassette domain-containing protein -
EUBC25_RS00645 (EUBC25_01260) 122219..123103 - 885 WP_230106336.1 hypothetical protein -
EUBC25_RS00650 (EUBC25_01270) 123096..123845 - 750 WP_230106337.1 hypothetical protein -
EUBC25_RS00655 (EUBC25_01280) 123864..125399 - 1536 WP_230106338.1 DUF6034 family protein -
EUBC25_RS00660 (EUBC25_01290) 125585..125845 - 261 WP_230106339.1 Txe/YoeB family addiction module toxin Toxin
EUBC25_RS00665 (EUBC25_01300) 125838..126101 - 264 WP_230106340.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EUBC25_RS00670 (EUBC25_01310) 126243..127442 - 1200 WP_230106341.1 metallophosphoesterase -
EUBC25_RS00675 (EUBC25_01320) 127402..129309 - 1908 WP_230106342.1 DUF975 family protein -
EUBC25_RS00680 (EUBC25_01330) 129316..130191 - 876 WP_230106343.1 mechanosensitive ion channel -
EUBC25_RS00685 (EUBC25_01340) 130204..131046 - 843 WP_230106344.1 peptidoglycan editing factor PgeF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10300.62 Da        Isoelectric Point: 8.8279

>T39741 WP_230106339.1 NZ_AP024845:c125845-125585 [Eubacterium sp. c-25]
MNKVFTENGWKDYIYWQTEDRKTLKKINRLLDDISRNGNTGIGKPEPLVGNLSGFWSRRINDTDRLVYRIDENNVYILAC
RYHYDI

Download         Length: 261 bp

>T39741 NZ_AP024845:c125845-125585 [Eubacterium sp. c-25]
ATGAATAAAGTTTTTACAGAAAATGGATGGAAAGACTATATATATTGGCAGACGGAAGACCGGAAAACATTGAAGAAAAT
AAATCGCCTTCTGGATGACATATCAAGAAATGGGAATACAGGCATAGGAAAACCAGAGCCGTTGGTTGGAAATCTGTCTG
GATTCTGGAGCAGAAGAATAAATGACACTGACAGGTTGGTATATAGAATAGATGAAAATAATGTTTACATTCTGGCTTGT
AGGTATCATTATGATATTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10199.60 Da        Isoelectric Point: 4.4791

>AT39741 WP_230106340.1 NZ_AP024845:c126101-125838 [Eubacterium sp. c-25]
MLAVNYTMLRENMKSCMDKVTDDYETLIVTRKNNKNVVMISEESYNNMMENLHLVGNKTNYDWLMESKKQLEQGMVSMHN
LDEAGDE

Download         Length: 264 bp

>AT39741 NZ_AP024845:c126101-125838 [Eubacterium sp. c-25]
ATGTTGGCTGTTAATTATACTATGCTTAGAGAAAATATGAAAAGCTGTATGGATAAAGTTACAGATGATTATGAAACGCT
GATCGTAACCAGAAAAAACAATAAAAATGTGGTTATGATTTCGGAAGAATCTTATAACAATATGATGGAAAATCTGCATC
TTGTCGGGAATAAGACAAATTATGACTGGCTGATGGAGTCTAAGAAACAATTAGAACAGGGAATGGTTTCCATGCACAAT
CTGGATGAGGCGGGCGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References