Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 5117..5739 | Replicon | plasmid pOCUAc18-3 |
| Accession | NZ_AP024805 | ||
| Organism | Acinetobacter baumannii strain OCU Ac18 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | OCUAc18_RS19505 | Protein ID | WP_004759377.1 |
| Coordinates | 5117..5512 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | N9QGM1 |
| Locus tag | OCUAc18_RS19510 | Protein ID | WP_004282079.1 |
| Coordinates | 5509..5739 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCUAc18_RS19465 (OCUAc18_38150) | 981..1502 | + | 522 | WP_026441245.1 | plasmid replication DNA-binding protein | - |
| OCUAc18_RS19470 (OCUAc18_38160) | 1702..1938 | - | 237 | WP_110975945.1 | hypothetical protein | - |
| OCUAc18_RS19475 (OCUAc18_38170) | 1965..2534 | - | 570 | WP_016659739.1 | hypothetical protein | - |
| OCUAc18_RS19480 (OCUAc18_38180) | 3185..3457 | - | 273 | WP_000369780.1 | NadS family protein | - |
| OCUAc18_RS19485 (OCUAc18_38190) | 3450..3770 | - | 321 | WP_000897310.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OCUAc18_RS19490 (OCUAc18_38200) | 3957..4154 | - | 198 | WP_000476222.1 | hypothetical protein | - |
| OCUAc18_RS19495 (OCUAc18_38210) | 4221..4448 | - | 228 | WP_000921865.1 | hypothetical protein | - |
| OCUAc18_RS19500 (OCUAc18_38220) | 4546..4761 | - | 216 | WP_000071892.1 | cold-shock protein | - |
| OCUAc18_RS19505 (OCUAc18_38230) | 5117..5512 | - | 396 | WP_004759377.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| OCUAc18_RS19510 (OCUAc18_38240) | 5509..5739 | - | 231 | WP_004282079.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| OCUAc18_RS19515 (OCUAc18_38250) | 6370..7653 | + | 1284 | WP_151838536.1 | hypothetical protein | - |
| OCUAc18_RS19520 (OCUAc18_38260) | 7703..7924 | - | 222 | WP_087548429.1 | hypothetical protein | - |
| OCUAc18_RS19525 (OCUAc18_38270) | 7921..8277 | - | 357 | WP_221255522.1 | hypothetical protein | - |
| OCUAc18_RS19530 (OCUAc18_38280) | 8317..9207 | - | 891 | WP_221255523.1 | MobA/MobL family protein | - |
| OCUAc18_RS19535 (OCUAc18_38290) | 9419..10141 | + | 723 | WP_221255524.1 | hypothetical protein | - |
| OCUAc18_RS19540 (OCUAc18_38300) | 10388..10582 | + | 195 | WP_151809600.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..10831 | 10831 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14919.24 Da Isoelectric Point: 6.2253
>T39733 WP_004759377.1 NZ_AP024805:c5512-5117 [Acinetobacter baumannii]
MIYLLDTNICIYVINNKPQHVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQDLQSTGKPIGSLDMLIAAHALALDVVLVTNNIKEFERIDGLKLENWV
MIYLLDTNICIYVINNKPQHVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQDLQSTGKPIGSLDMLIAAHALALDVVLVTNNIKEFERIDGLKLENWV
Download Length: 396 bp
>T39733 NZ_AP024805:c5512-5117 [Acinetobacter baumannii]
ATGATTTACCTCTTAGACACAAATATTTGTATCTATGTCATCAATAATAAGCCTCAACACGTTTTTGAACGCTTTAAGCA
ATATCAACTCGGCCAGCTCGCAATTTCAAGTATCACGGCATCCGAGCTGGCTTTTGGTGTAGAGAAGTCTGGATCTGAAC
GCAATAAACAGGCGTTAAACAAGTTTTTGTCACCTTTAGAGATTCTTCCTTACGATGAACAAGCAATTTGGCATTACGCC
AAATTACGCCAAGATCTTCAATCTACAGGTAAACCGATTGGCAGCTTAGATATGCTGATCGCTGCTCATGCTTTGGCATT
GGATGTTGTATTAGTCACAAACAATATCAAAGAATTTGAACGGATTGATGGTCTGAAGCTAGAGAATTGGGTCTAA
ATGATTTACCTCTTAGACACAAATATTTGTATCTATGTCATCAATAATAAGCCTCAACACGTTTTTGAACGCTTTAAGCA
ATATCAACTCGGCCAGCTCGCAATTTCAAGTATCACGGCATCCGAGCTGGCTTTTGGTGTAGAGAAGTCTGGATCTGAAC
GCAATAAACAGGCGTTAAACAAGTTTTTGTCACCTTTAGAGATTCTTCCTTACGATGAACAAGCAATTTGGCATTACGCC
AAATTACGCCAAGATCTTCAATCTACAGGTAAACCGATTGGCAGCTTAGATATGCTGATCGCTGCTCATGCTTTGGCATT
GGATGTTGTATTAGTCACAAACAATATCAAAGAATTTGAACGGATTGATGGTCTGAAGCTAGAGAATTGGGTCTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8738.96 Da Isoelectric Point: 4.7708
>AT39733 WP_004282079.1 NZ_AP024805:c5739-5509 [Acinetobacter baumannii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAVNEFESGFQLERADQGEQFREEFK
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAVNEFESGFQLERADQGEQFREEFK
Download Length: 231 bp
>AT39733 NZ_AP024805:c5739-5509 [Acinetobacter baumannii]
ATGGAAATTGCGAAAGTATTTCAAACTGGTCGCAGTCAGGCTGTTCGCTTGCCTAAAGCCTTTCGCTTTAATGGCACGGA
AGTGGCCATCAAAAGCTTCGGACGTGGCGTTTTGTTGATGCCAATCGATAATCCTTGGGATGTAATGCTTGAAGCAGTGA
ATGAGTTCGAATCTGGATTCCAGTTAGAACGTGCTGATCAGGGGGAACAGTTCCGTGAGGAGTTCAAATGA
ATGGAAATTGCGAAAGTATTTCAAACTGGTCGCAGTCAGGCTGTTCGCTTGCCTAAAGCCTTTCGCTTTAATGGCACGGA
AGTGGCCATCAAAAGCTTCGGACGTGGCGTTTTGTTGATGCCAATCGATAATCCTTGGGATGTAATGCTTGAAGCAGTGA
ATGAGTTCGAATCTGGATTCCAGTTAGAACGTGCTGATCAGGGGGAACAGTTCCGTGAGGAGTTCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|