Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3435999..3436652 Replicon chromosome
Accession NZ_AP024802
Organism Acinetobacter baumannii strain OCU Ac18

Toxin (Protein)


Gene name cptA Uniprot ID A0A829RKD8
Locus tag OCUAc18_RS16625 Protein ID WP_002125600.1
Coordinates 3435999..3436388 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag OCUAc18_RS16630 Protein ID WP_001288210.1
Coordinates 3436395..3436652 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCUAc18_RS16610 (OCUAc18_32520) 3431117..3433312 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
OCUAc18_RS16615 (OCUAc18_32530) 3433500..3434066 - 567 WP_000651536.1 rhombosortase -
OCUAc18_RS16620 (OCUAc18_32540) 3434144..3435229 - 1086 WP_000049106.1 hypothetical protein -
OCUAc18_RS16625 (OCUAc18_32550) 3435999..3436388 - 390 WP_002125600.1 hypothetical protein Toxin
OCUAc18_RS16630 (OCUAc18_32560) 3436395..3436652 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
OCUAc18_RS16635 (OCUAc18_32570) 3436840..3438012 + 1173 WP_002125555.1 acyl-CoA dehydrogenase family protein -
OCUAc18_RS16640 (OCUAc18_32580) 3438061..3439551 - 1491 WP_002125480.1 NAD(P)/FAD-dependent oxidoreductase -
OCUAc18_RS16645 (OCUAc18_32590) 3439733..3440110 - 378 WP_001216380.1 50S ribosomal protein L17 -
OCUAc18_RS16650 (OCUAc18_32600) 3440129..3441136 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15662.98 Da        Isoelectric Point: 10.4623

>T39731 WP_002125600.1 NZ_AP024802:c3436388-3435999 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKIWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T39731 NZ_AP024802:c3436388-3435999 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT39731 WP_001288210.1 NZ_AP024802:c3436652-3436395 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT39731 NZ_AP024802:c3436652-3436395 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RKD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References