Detailed information of TA system TA039730

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2122640..2124276
• Replicon: chromosome
• Accession: NZ_AP024802
• Organism: Acinetobacter baumannii strain OCU Ac18

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A158LVC8
• Locus tag: OCUAc18_RS10410
• Protein ID: WP_002163265.1
• Coordinates: 2122945..2124276 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: OCUAc18_RS10405
• Protein ID: WP_001101310.1
• Coordinates: 2122640..2122948 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAc18_RS10365 (OCUAc18_20270)	2118058..2118552	-	495	WP_004834840.1	phage antirepressor KilAC domain-containing protein	-
OCUAc18_RS10370 (OCUAc18_20280)	2118674..2119054	-	381	WP_004834837.1	hypothetical protein	-
OCUAc18_RS10375 (OCUAc18_20290)	2119185..2119388	-	204	WP_004834836.1	hypothetical protein	-
OCUAc18_RS10380 (OCUAc18_20300)	2119531..2119878	+	348	WP_004834833.1	hypothetical protein	-
OCUAc18_RS10385 (OCUAc18_20310)	2119908..2120840	-	933	WP_049590967.1	IS5-like element ISAba13 family transposase	-
OCUAc18_RS10390 (OCUAc18_20320)	2120882..2121055	+	174	WP_002126882.1	hypothetical protein	-
OCUAc18_RS10395 (OCUAc18_20330)	2121108..2121272	-	165	WP_153309835.1	hypothetical protein	-
OCUAc18_RS10400 (OCUAc18_20340)	2121356..2121916	-	561	WP_002126886.1	TetR/AcrR family transcriptional regulator	-
OCUAc18_RS10405 (OCUAc18_20350)	2122640..2122948	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
OCUAc18_RS10410 (OCUAc18_20360)	2122945..2124276	-	1332	WP_002163265.1	HipA domain-containing protein	Toxin
OCUAc18_RS10415 (OCUAc18_20370)	2124572..2125012	+	441	WP_221255291.1	HD domain-containing protein	-
OCUAc18_RS10420 (OCUAc18_20380)	2125048..2125692	-	645	WP_002163276.1	hypothetical protein	-
OCUAc18_RS10425 (OCUAc18_20390)	2125704..2126674	-	971	Protein_2049	5'/3'-nucleotidase SurE	-
OCUAc18_RS10430 (OCUAc18_20400)	2126801..2127961	-	1161	WP_221255292.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2119908..2120840	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51233.35 Da
• Isoelectric Point: 4.9177

>T39730 WP_002163265.1 NZ_AP024802:c2124276-2122945 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SSGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T39730 NZ_AP024802:c2124276-2122945 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAGGCTTTACTAAATAAAAACTGGATAGATATAGCAGAACTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACACGAATCGGACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTAGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAATTACTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAAAAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAAACGTAGCGAGATTGATT
GCGATATTCTCAGAGCCGAATATTATTATTATCAGATACTCAATGAGTTAGGTTTCAACACAATTGAAACAACCCAAATG
AAGCTCATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGTGACTTACTC
AATATCATTTTTGGTAATTCAGATAACCATGGGCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GTGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCGACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCCAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT39730 WP_001101310.1 NZ_AP024802:c2122948-2122640 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT39730 NZ_AP024802:c2122948-2122640 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGCCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A158LVC8