Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 112872..113385 Replicon chromosome
Accession NZ_AP024802
Organism Acinetobacter baumannii strain OCU Ac18

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2L2M0A2
Locus tag OCUAc18_RS00540 Protein ID WP_000203952.1
Coordinates 112872..113135 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S7WSW9
Locus tag OCUAc18_RS00545 Protein ID WP_000557943.1
Coordinates 113122..113385 (-) Length 88 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCUAc18_RS00510 (OCUAc18_00950) 108962..110392 + 1431 WP_000178999.1 amino acid permease -
OCUAc18_RS00515 (OCUAc18_00960) 110450..110794 - 345 Protein_98 LysR substrate-binding domain-containing protein -
OCUAc18_RS00520 110833..112066 - 1234 Protein_99 IS3 family transposase -
OCUAc18_RS00525 (OCUAc18_01000) 112125..112436 - 312 WP_079281501.1 LysR substrate-binding domain-containing protein -
OCUAc18_RS00530 112576..112674 + 99 Protein_101 IS5/IS1182 family transposase -
OCUAc18_RS00535 112706..112813 - 108 Protein_102 transposase domain-containing protein -
OCUAc18_RS00540 (OCUAc18_01010) 112872..113135 - 264 WP_000203952.1 Txe/YoeB family addiction module toxin Toxin
OCUAc18_RS00545 (OCUAc18_01020) 113122..113385 - 264 WP_000557943.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OCUAc18_RS00550 (OCUAc18_01030) 113801..117148 + 3348 WP_025467233.1 DEAD/DEAH box helicase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-87)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 88 a.a.        Molecular weight: 10664.10 Da        Isoelectric Point: 8.4894

>T39728 WP_000203952.1 NZ_AP024802:c113135-112872 [Acinetobacter baumannii]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
IQCRFHY

Download         Length: 264 bp

>T39728 NZ_AP024802:c113135-112872 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.04 Da        Isoelectric Point: 5.5940

>AT39728 WP_000557943.1 NZ_AP024802:c113385-113122 [Acinetobacter baumannii]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Download         Length: 264 bp

>AT39728 NZ_AP024802:c113385-113122 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2L2M0A2


Antitoxin

Source ID Structure
AlphaFold DB S7WSW9

References