Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumAB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 30401..30985 | Replicon | plasmid pOCUAc17-1 |
| Accession | NZ_AP024799 | ||
| Organism | Acinetobacter pittii strain OCU Ac17 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | N9JY46 |
| Locus tag | OCUAc17_RS19295 | Protein ID | WP_000286963.1 |
| Coordinates | 30401..30703 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | PumB | Uniprot ID | - |
| Locus tag | OCUAc17_RS19300 | Protein ID | WP_000985610.1 |
| Coordinates | 30704..30985 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCUAc17_RS19265 (OCUAc17_37600) | 25534..26046 | - | 513 | WP_001089572.1 | SMI1/KNR4 family protein | - |
| OCUAc17_RS19270 (OCUAc17_37610) | 26201..26713 | - | 513 | WP_086376834.1 | hypothetical protein | - |
| OCUAc17_RS19275 (OCUAc17_37620) | 26730..27725 | - | 996 | WP_086376833.1 | AraC family transcriptional regulator | - |
| OCUAc17_RS19280 (OCUAc17_37630) | 27772..28602 | - | 831 | WP_086376832.1 | oxidoreductase | - |
| OCUAc17_RS19285 (OCUAc17_37640) | 28941..29552 | + | 612 | WP_000571899.1 | recombinase family protein | - |
| OCUAc17_RS19290 (OCUAc17_37650) | 29768..30286 | + | 519 | WP_086376831.1 | tetratricopeptide repeat protein | - |
| OCUAc17_RS19295 (OCUAc17_37660) | 30401..30703 | + | 303 | WP_000286963.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OCUAc17_RS19300 (OCUAc17_37670) | 30704..30985 | + | 282 | WP_000985610.1 | putative addiction module antidote protein | Antitoxin |
| OCUAc17_RS19305 (OCUAc17_37680) | 31083..31376 | + | 294 | WP_221255110.1 | hypothetical protein | - |
| OCUAc17_RS19310 | 31400..32547 | + | 1148 | WP_087013213.1 | IS3 family transposase | - |
| OCUAc17_RS19315 (OCUAc17_37710) | 32563..32811 | - | 249 | WP_226381322.1 | hypothetical protein | - |
| OCUAc17_RS19320 (OCUAc17_37720) | 32927..33283 | + | 357 | WP_086376473.1 | hypothetical protein | - |
| OCUAc17_RS19325 (OCUAc17_37730) | 33532..33894 | - | 363 | Protein_44 | plasmid replication DNA-binding protein | - |
| OCUAc17_RS19330 (OCUAc17_37740) | 33928..34152 | - | 225 | WP_126026108.1 | hypothetical protein | - |
| OCUAc17_RS19335 | 34302..34397 | - | 96 | Protein_46 | DNA-binding protein | - |
| OCUAc17_RS19340 | 34395..34565 | - | 171 | Protein_47 | IS3 family transposase | - |
| OCUAc17_RS19345 (OCUAc17_37760) | 34741..35025 | - | 285 | WP_005071539.1 | putative quinol monooxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..69156 | 69156 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11545.02 Da Isoelectric Point: 4.6838
>T39725 WP_000286963.1 NZ_AP024799:30401-30703 [Acinetobacter pittii]
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
Download Length: 303 bp
>T39725 NZ_AP024799:30401-30703 [Acinetobacter pittii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGTGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGTTGTAA
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGTGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGTTGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10109.67 Da Isoelectric Point: 8.0018
>AT39725 WP_000985610.1 NZ_AP024799:30704-30985 [Acinetobacter pittii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
Download Length: 282 bp
>AT39725 NZ_AP024799:30704-30985 [Acinetobacter pittii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|