Detailed information of TA system TA039722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2652639..2653318
• Replicon: chromosome
• Accession: NZ_AP024798
• Organism: Acinetobacter pittii strain OCU Ac17

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: OCUAc17_RS12760
• Protein ID: WP_000838146.1
• Coordinates: 2653136..2653318 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: OCUAc17_RS12755
• Protein ID: WP_000966688.1
• Coordinates: 2652639..2653043 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAc17_RS12735	2648835..2649982	+	1148	WP_087013213.1	IS3 family transposase	-
OCUAc17_RS12740 (OCUAc17_24840)	2650001..2651464	-	1464	Protein_2508	tape measure protein	-
OCUAc17_RS12745 (OCUAc17_24850)	2651595..2651858	-	264	WP_001275792.1	hypothetical protein	-
OCUAc17_RS12750 (OCUAc17_24860)	2651860..2652540	-	681	WP_000721572.1	hypothetical protein	-
OCUAc17_RS12755 (OCUAc17_24870)	2652639..2653043	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OCUAc17_RS12760 (OCUAc17_24880)	2653136..2653318	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
OCUAc17_RS12765 (OCUAc17_24890)	2653644..2654159	-	516	WP_025464105.1	hypothetical protein	-
OCUAc17_RS12770 (OCUAc17_24900)	2654230..2655147	-	918	WP_002121543.1	phage tail tube protein	-
OCUAc17_RS12775 (OCUAc17_24910)	2655200..2656528	-	1329	WP_023187966.1	hypothetical protein	-
OCUAc17_RS12780 (OCUAc17_24920)	2656528..2656881	-	354	WP_002121621.1	hypothetical protein	-
OCUAc17_RS12785 (OCUAc17_24930)	2656950..2657348	-	399	WP_032021503.1	phage tail terminator-like protein	-
OCUAc17_RS12790 (OCUAc17_24940)	2657350..2657718	-	369	WP_005135680.1	hypothetical protein	-
OCUAc17_RS12795 (OCUAc17_24950)	2657690..2658100	-	411	WP_221255024.1	hypothetical protein	-
OCUAc17_RS12800 (OCUAc17_24960)	2658111..2658281	-	171	WP_000220307.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2635712..2685476	49764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T39722 WP_000838146.1 NZ_AP024798:c2653318-2653136 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T39722 NZ_AP024798:c2653318-2653136 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT39722 WP_000966688.1 NZ_AP024798:c2653043-2652639 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT39722 NZ_AP024798:c2653043-2652639 [Acinetobacter pittii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6