Detailed information of TA system TA039721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1232409..1233060
• Replicon: chromosome
• Accession: NZ_AP024798
• Organism: Acinetobacter pittii strain OCU Ac17

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: OCUAc17_RS05875
• Protein ID: WP_000838150.1
• Coordinates: 1232409..1232591 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: OCUAc17_RS05880
• Protein ID: WP_078210450.1
• Coordinates: 1232656..1233060 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAc17_RS05830 (OCUAc17_11120)	1227684..1227854	+	171	WP_171251325.1	hypothetical protein	-
OCUAc17_RS05835 (OCUAc17_11130)	1227866..1228279	+	414	WP_057095596.1	hypothetical protein	-
OCUAc17_RS05840 (OCUAc17_11140)	1228245..1228613	+	369	WP_057090139.1	hypothetical protein	-
OCUAc17_RS05845 (OCUAc17_11150)	1228615..1229013	+	399	WP_125530084.1	hypothetical protein	-
OCUAc17_RS05850 (OCUAc17_11160)	1229015..1229227	+	213	WP_049069243.1	hypothetical protein	-
OCUAc17_RS05855 (OCUAc17_11170)	1229336..1230265	+	930	WP_031968587.1	phage tail tube protein	-
OCUAc17_RS05860 (OCUAc17_11180)	1230311..1230583	+	273	Protein_1137	hypothetical protein	-
OCUAc17_RS19720	1231829..1232077	+	249	Protein_1139	hypothetical protein	-
OCUAc17_RS05875 (OCUAc17_11220)	1232409..1232591	+	183	WP_000838150.1	type II toxin-antitoxin system HicA family toxin	Toxin
OCUAc17_RS05880 (OCUAc17_11230)	1232656..1233060	+	405	WP_078210450.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OCUAc17_RS05885 (OCUAc17_11240)	1233156..1233674	+	519	WP_032023512.1	DUF4468 domain-containing protein	-
OCUAc17_RS05890 (OCUAc17_11250)	1233771..1237760	+	3990	WP_221255073.1	tape measure protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1203683..1261164	57481

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6622.83 Da
• Isoelectric Point: 10.7364

>T39721 WP_000838150.1 NZ_AP024798:1232409-1232591 [Acinetobacter pittii]
VKSLDLVKMIEADGWYLVRVKGSHHHFKHPTKGGLVTIPHPKKELPSGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T39721 NZ_AP024798:1232409-1232591 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAGTCAAAATGATTGAAGCAGACGGTTGGTACTTAGTTAGGGTTAAAGGAAGTCATCATCACTT
CAAACATCCAACTAAAGGGGGCTTAGTTACTATCCCTCACCCAAAAAAGGAATTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14601.58 Da
• Isoelectric Point: 4.4162

>AT39721 WP_078210450.1 NZ_AP024798:1232656-1233060 [Acinetobacter pittii]
MLYPIAIERGNDTEAYGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDDADYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIHIIDENVGKGKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT39721 NZ_AP024798:1232656-1233060 [Acinetobacter pittii]
ATGTTGTATCCAATTGCTATAGAAAGAGGTAACGACACCGAGGCTTATGGTGTTACTGTTCCAGATATTCCAGGTTGTTT
TAGTGCTGGCGACACTTTAGAGGAAGCTATCGAGAACGTAAAAGAGGCTATTTCTGGCCATCTAGAAATCCTTGCTGAAG
ATGGCGAGGAGATTCCATTAGCATCTGATGTAAGTAAGTTTATAGATGATGCTGACTATAAAGGAATGATCTGGGCAGTT
ACAGAAGTTGATGTTAGTCGTTACTTAGGTAAGCCAGAAAAAATCAATGTCACTTTACCAAGTCGTTTAATTCATATAAT
TGATGAAAATGTAGGTAAAGGAAAAAGATTTAAAACCCGATCTGCATTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA