Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1232409..1233060 Replicon chromosome
Accession NZ_AP024798
Organism Acinetobacter pittii strain OCU Ac17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OCUAc17_RS05875 Protein ID WP_000838150.1
Coordinates 1232409..1232591 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OCUAc17_RS05880 Protein ID WP_078210450.1
Coordinates 1232656..1233060 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCUAc17_RS05830 (OCUAc17_11120) 1227684..1227854 + 171 WP_171251325.1 hypothetical protein -
OCUAc17_RS05835 (OCUAc17_11130) 1227866..1228279 + 414 WP_057095596.1 hypothetical protein -
OCUAc17_RS05840 (OCUAc17_11140) 1228245..1228613 + 369 WP_057090139.1 hypothetical protein -
OCUAc17_RS05845 (OCUAc17_11150) 1228615..1229013 + 399 WP_125530084.1 hypothetical protein -
OCUAc17_RS05850 (OCUAc17_11160) 1229015..1229227 + 213 WP_049069243.1 hypothetical protein -
OCUAc17_RS05855 (OCUAc17_11170) 1229336..1230265 + 930 WP_031968587.1 phage tail tube protein -
OCUAc17_RS05860 (OCUAc17_11180) 1230311..1230583 + 273 Protein_1137 hypothetical protein -
OCUAc17_RS19720 1231829..1232077 + 249 Protein_1139 hypothetical protein -
OCUAc17_RS05875 (OCUAc17_11220) 1232409..1232591 + 183 WP_000838150.1 type II toxin-antitoxin system HicA family toxin Toxin
OCUAc17_RS05880 (OCUAc17_11230) 1232656..1233060 + 405 WP_078210450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCUAc17_RS05885 (OCUAc17_11240) 1233156..1233674 + 519 WP_032023512.1 DUF4468 domain-containing protein -
OCUAc17_RS05890 (OCUAc17_11250) 1233771..1237760 + 3990 WP_221255073.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1203683..1261164 57481


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6622.83 Da        Isoelectric Point: 10.7364

>T39721 WP_000838150.1 NZ_AP024798:1232409-1232591 [Acinetobacter pittii]
VKSLDLVKMIEADGWYLVRVKGSHHHFKHPTKGGLVTIPHPKKELPSGTVKSILKQAGLN

Download         Length: 183 bp

>T39721 NZ_AP024798:1232409-1232591 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAGTCAAAATGATTGAAGCAGACGGTTGGTACTTAGTTAGGGTTAAAGGAAGTCATCATCACTT
CAAACATCCAACTAAAGGGGGCTTAGTTACTATCCCTCACCCAAAAAAGGAATTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14601.58 Da        Isoelectric Point: 4.4162

>AT39721 WP_078210450.1 NZ_AP024798:1232656-1233060 [Acinetobacter pittii]
MLYPIAIERGNDTEAYGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDDADYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIHIIDENVGKGKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT39721 NZ_AP024798:1232656-1233060 [Acinetobacter pittii]
ATGTTGTATCCAATTGCTATAGAAAGAGGTAACGACACCGAGGCTTATGGTGTTACTGTTCCAGATATTCCAGGTTGTTT
TAGTGCTGGCGACACTTTAGAGGAAGCTATCGAGAACGTAAAAGAGGCTATTTCTGGCCATCTAGAAATCCTTGCTGAAG
ATGGCGAGGAGATTCCATTAGCATCTGATGTAAGTAAGTTTATAGATGATGCTGACTATAAAGGAATGATCTGGGCAGTT
ACAGAAGTTGATGTTAGTCGTTACTTAGGTAAGCCAGAAAAAATCAATGTCACTTTACCAAGTCGTTTAATTCATATAAT
TGATGAAAATGTAGGTAAAGGAAAAAGATTTAAAACCCGATCTGCATTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References