Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 475368..476021 Replicon chromosome
Accession NZ_AP024798
Organism Acinetobacter pittii strain OCU Ac17

Toxin (Protein)


Gene name cptA Uniprot ID A0A009NMD1
Locus tag OCUAc17_RS02320 Protein ID WP_005804615.1
Coordinates 475632..476021 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag OCUAc17_RS02315 Protein ID WP_002117064.1
Coordinates 475368..475625 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCUAc17_RS02295 (OCUAc17_04410) 470881..471888 + 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -
OCUAc17_RS02300 (OCUAc17_04420) 471907..472284 + 378 WP_002049717.1 50S ribosomal protein L17 -
OCUAc17_RS02305 (OCUAc17_04430) 472466..473956 + 1491 WP_002116796.1 NAD(P)/FAD-dependent oxidoreductase -
OCUAc17_RS02310 (OCUAc17_04440) 474007..475179 - 1173 WP_025464188.1 acyl-CoA dehydrogenase family protein -
OCUAc17_RS02315 (OCUAc17_04450) 475368..475625 + 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
OCUAc17_RS02320 (OCUAc17_04460) 475632..476021 + 390 WP_005804615.1 hypothetical protein Toxin
OCUAc17_RS02325 (OCUAc17_04470) 476792..477880 + 1089 WP_005804616.1 hypothetical protein -
OCUAc17_RS02330 (OCUAc17_04480) 477965..478540 + 576 WP_025464189.1 rhombosortase -
OCUAc17_RS02335 (OCUAc17_04490) 478720..480930 + 2211 WP_005804618.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15553.65 Da        Isoelectric Point: 8.7390

>T39720 WP_005804615.1 NZ_AP024798:475632-476021 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSIAYFSKKEI
YRGEITKIIDYQLFVVIYFEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T39720 NZ_AP024798:475632-476021 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGATTGCATATTTTTCGAAAAAAGAAATT
TACCGTGGGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATTTTGAAGAAACTCCTACGAATATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT39720 WP_002117064.1 NZ_AP024798:475368-475625 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT39720 NZ_AP024798:475368-475625 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGTGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAATTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGCTAGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAGCCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009NMD1

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References