39680

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 143594..144116 Replicon plasmid pMTY12138
Accession NZ_AP024789
Organism Klebsiella pneumoniae strain TUM12138

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag K6K06_RS26745 Protein ID WP_038991638.1
Coordinates 143832..144116 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag K6K06_RS26740 Protein ID WP_004181777.1
Coordinates 143594..143842 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K06_RS26720 (TUM12138_51490) 138803..139639 - 837 WP_014386523.1 hypothetical protein -
K6K06_RS26725 (TUM12138_51500) 139686..140039 - 354 WP_004181774.1 hypothetical protein -
K6K06_RS26730 (TUM12138_51510) 140184..141170 - 987 WP_086528942.1 hypothetical protein -
K6K06_RS26735 (TUM12138_51530) 141504..143303 - 1800 WP_038991636.1 ATP-dependent helicase -
K6K06_RS26740 (TUM12138_51540) 143594..143842 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6K06_RS26745 (TUM12138_51550) 143832..144116 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6K06_RS26750 (TUM12138_51560) 144270..145457 + 1188 WP_094284697.1 RNA-guided endonuclease TnpB family protein -
K6K06_RS28025 (TUM12138_51570) 145502..145873 - 372 WP_227627908.1 hypothetical protein -
K6K06_RS28030 (TUM12138_51580) 145870..146214 - 345 WP_223811496.1 hypothetical protein -
K6K06_RS26760 (TUM12138_51600) 147156..148004 + 849 WP_014386517.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..216384 216384
- flank IS/Tn - - 144270..145457 1187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T39680 WP_038991638.1 NZ_AP024789:143832-144116 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T39680 NZ_AP024789:143832-144116 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT39680 WP_004181777.1 NZ_AP024789:143594-143842 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT39680 NZ_AP024789:143594-143842 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCAATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References