Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4723023..4723539 Replicon chromosome
Accession NZ_AP024788
Organism Klebsiella pneumoniae strain TUM12138

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K6K06_RS23290 Protein ID WP_002886902.1
Coordinates 4723023..4723307 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6K06_RS23295 Protein ID WP_002886901.1
Coordinates 4723297..4723539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K06_RS23265 (TUM12138_44840) 4718507..4718770 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K6K06_RS23270 4718900..4719073 + 174 WP_002886906.1 hypothetical protein -
K6K06_RS23275 (TUM12138_44850) 4719076..4719819 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6K06_RS23280 (TUM12138_44860) 4720176..4722314 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K6K06_RS23285 (TUM12138_44870) 4722555..4723019 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6K06_RS23290 (TUM12138_44880) 4723023..4723307 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6K06_RS23295 (TUM12138_44890) 4723297..4723539 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6K06_RS23300 (TUM12138_44900) 4723617..4725527 - 1911 WP_004152270.1 PRD domain-containing protein -
K6K06_RS23305 (TUM12138_44910) 4725550..4726704 - 1155 WP_002886900.1 lactonase family protein -
K6K06_RS23310 (TUM12138_44920) 4726770..4727510 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T39674 WP_002886902.1 NZ_AP024788:c4723307-4723023 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T39674 NZ_AP024788:c4723307-4723023 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT39674 WP_002886901.1 NZ_AP024788:c4723539-4723297 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT39674 NZ_AP024788:c4723539-4723297 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References