Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 111191..111942 Replicon plasmid pMTY12137
Accession NZ_AP024785
Organism Klebsiella pneumoniae strain TUM12137

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag K6K11_RS26555 Protein ID WP_014386536.1
Coordinates 111191..111673 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag K6K11_RS26560 Protein ID WP_004902250.1
Coordinates 111664..111942 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K11_RS26535 (TUM12137_51080) 107590..108237 - 648 WP_014386537.1 EcsC family protein -
K6K11_RS26540 (TUM12137_51090) 108264..109019 - 756 WP_004902235.1 DUF2971 domain-containing protein -
K6K11_RS26545 (TUM12137_51100) 109120..109512 - 393 WP_177332577.1 hypothetical protein -
K6K11_RS26550 (TUM12137_51110) 109617..110156 - 540 WP_004902239.1 hypothetical protein -
K6K11_RS26555 (TUM12137_51140) 111191..111673 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
K6K11_RS26560 (TUM12137_51150) 111664..111942 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
K6K11_RS26565 (TUM12137_51160) 112061..112273 - 213 WP_004902255.1 hypothetical protein -
K6K11_RS26570 (TUM12137_51170) 112381..112722 - 342 WP_221276803.1 hypothetical protein -
K6K11_RS26575 (TUM12137_51190) 113627..113941 + 315 WP_023288299.1 hypothetical protein -
K6K11_RS26580 (TUM12137_51200) 114271..115275 - 1005 WP_000427623.1 IS110-like element IS4321 family transposase -
K6K11_RS26585 115375..115664 - 290 Protein_122 Tn3 family transposase -
K6K11_RS26590 (TUM12137_51210) 115715..115912 - 198 WP_024262939.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..216322 216322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T39656 WP_014386536.1 NZ_AP024785:c111673-111191 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T39656 NZ_AP024785:c111673-111191 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT39656 WP_004902250.1 NZ_AP024785:c111942-111664 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT39656 NZ_AP024785:c111942-111664 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCTAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References