Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4722832..4723348 Replicon chromosome
Accession NZ_AP024778
Organism Klebsiella pneumoniae strain TUM12135

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K6J93_RS23275 Protein ID WP_002886902.1
Coordinates 4722832..4723116 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6J93_RS23280 Protein ID WP_002886901.1
Coordinates 4723106..4723348 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J93_RS23250 (TUM12135_44830) 4718316..4718579 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K6J93_RS23255 4718709..4718882 + 174 WP_002886906.1 hypothetical protein -
K6J93_RS23260 (TUM12135_44840) 4718885..4719628 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6J93_RS23265 (TUM12135_44850) 4719985..4722123 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K6J93_RS23270 (TUM12135_44860) 4722364..4722828 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6J93_RS23275 (TUM12135_44870) 4722832..4723116 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J93_RS23280 (TUM12135_44880) 4723106..4723348 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J93_RS23285 (TUM12135_44890) 4723426..4725336 - 1911 WP_004152270.1 PRD domain-containing protein -
K6J93_RS23290 (TUM12135_44900) 4725359..4726513 - 1155 WP_002886900.1 lactonase family protein -
K6J93_RS23295 (TUM12135_44910) 4726579..4727319 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T39613 WP_002886902.1 NZ_AP024778:c4723116-4722832 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T39613 NZ_AP024778:c4723116-4722832 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT39613 WP_002886901.1 NZ_AP024778:c4723348-4723106 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT39613 NZ_AP024778:c4723348-4723106 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References