Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874156..874813 Replicon chromosome
Accession NZ_AP024766
Organism Klebsiella pneumoniae strain TUM12131

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K6J85_RS04410 Protein ID WP_002916310.1
Coordinates 874403..874813 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6J85_RS04405 Protein ID WP_002916312.1
Coordinates 874156..874422 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J85_RS04380 (TUM12131_08530) 869312..870745 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K6J85_RS04385 (TUM12131_08540) 870864..871592 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6J85_RS04390 (TUM12131_08550) 871642..871953 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K6J85_RS04395 (TUM12131_08560) 872117..872776 + 660 WP_002916317.1 hemolysin III family protein -
K6J85_RS04400 (TUM12131_08570) 872927..873910 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K6J85_RS04405 (TUM12131_08580) 874156..874422 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6J85_RS04410 (TUM12131_08590) 874403..874813 + 411 WP_002916310.1 protein YgfX Toxin
K6J85_RS04415 (TUM12131_08600) 874820..875341 - 522 WP_002916308.1 flavodoxin FldB -
K6J85_RS04420 (TUM12131_08610) 875442..876338 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6J85_RS04425 (TUM12131_08620) 876361..877074 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6J85_RS04430 (TUM12131_08630) 877080..878813 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T39525 WP_002916310.1 NZ_AP024766:874403-874813 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T39525 NZ_AP024766:874403-874813 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT39525 WP_002916312.1 NZ_AP024766:874156-874422 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT39525 NZ_AP024766:874156-874422 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References