Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4789867..4790383 Replicon chromosome
Accession NZ_AP024760
Organism Klebsiella pneumoniae strain TUM12129

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K6J88_RS23695 Protein ID WP_002886902.1
Coordinates 4789867..4790151 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6J88_RS23700 Protein ID WP_002886901.1
Coordinates 4790141..4790383 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J88_RS23670 (TUM12129_45740) 4785351..4785614 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K6J88_RS23675 4785744..4785917 + 174 WP_002886906.1 hypothetical protein -
K6J88_RS23680 (TUM12129_45750) 4785920..4786663 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6J88_RS23685 (TUM12129_45760) 4787020..4789158 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K6J88_RS23690 (TUM12129_45770) 4789399..4789863 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6J88_RS23695 (TUM12129_45780) 4789867..4790151 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J88_RS23700 (TUM12129_45790) 4790141..4790383 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J88_RS23705 (TUM12129_45800) 4790461..4792371 - 1911 WP_004152270.1 PRD domain-containing protein -
K6J88_RS23710 (TUM12129_45810) 4792394..4793548 - 1155 WP_002886900.1 lactonase family protein -
K6J88_RS23715 (TUM12129_45820) 4793614..4794354 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T39499 WP_002886902.1 NZ_AP024760:c4790151-4789867 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T39499 NZ_AP024760:c4790151-4789867 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT39499 WP_002886901.1 NZ_AP024760:c4790383-4790141 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT39499 NZ_AP024760:c4790383-4790141 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References