Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2057480..2058137 Replicon chromosome
Accession NZ_AP024756
Organism Klebsiella pneumoniae strain TUM12128

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K6J96_RS10080 Protein ID WP_002916310.1
Coordinates 2057480..2057890 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6J96_RS10085 Protein ID WP_002916312.1
Coordinates 2057871..2058137 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J96_RS10060 (TUM12128_19150) 2053480..2055213 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
K6J96_RS10065 (TUM12128_19160) 2055219..2055932 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6J96_RS10070 (TUM12128_19170) 2055955..2056851 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6J96_RS10075 (TUM12128_19180) 2056952..2057473 + 522 WP_002916308.1 flavodoxin FldB -
K6J96_RS10080 (TUM12128_19190) 2057480..2057890 - 411 WP_002916310.1 protein YgfX Toxin
K6J96_RS10085 (TUM12128_19200) 2057871..2058137 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6J96_RS10090 (TUM12128_19210) 2058383..2059366 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K6J96_RS10095 (TUM12128_19220) 2059517..2060176 - 660 WP_002916317.1 hemolysin III family protein -
K6J96_RS10100 (TUM12128_19230) 2060340..2060651 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K6J96_RS10105 (TUM12128_19240) 2060701..2061429 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6J96_RS10110 (TUM12128_19250) 2061548..2062981 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T39474 WP_002916310.1 NZ_AP024756:c2057890-2057480 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T39474 NZ_AP024756:c2057890-2057480 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT39474 WP_002916312.1 NZ_AP024756:c2058137-2057871 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT39474 NZ_AP024756:c2058137-2057871 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References