Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1602032..1602835 | Replicon | chromosome |
| Accession | NZ_AP024742 | ||
| Organism | Staphylococcus aureus strain 59736 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2C9TYR5 |
| Locus tag | OCX51_RS07790 | Protein ID | WP_001573840.1 |
| Coordinates | 1602374..1602835 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | OCX51_RS07785 | Protein ID | WP_001573842.1 |
| Coordinates | 1602032..1602361 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCX51_RS07725 (1597126) | 1597126..1598292 | - | 1167 | WP_000762532.1 | DUF2800 domain-containing protein | - |
| OCX51_RS07730 (1598289) | 1598289..1598651 | - | 363 | WP_152064739.1 | hypothetical protein | - |
| OCX51_RS07735 (1598666) | 1598666..1598989 | - | 324 | WP_000174998.1 | hypothetical protein | - |
| OCX51_RS07740 (1599067) | 1599067..1599228 | - | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| OCX51_RS07745 (1599241) | 1599241..1599504 | - | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| OCX51_RS07750 (1599529) | 1599529..1599744 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| OCX51_RS07755 (1599799) | 1599799..1600164 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| OCX51_RS07760 (1600133) | 1600133..1600378 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| OCX51_RS07765 (1600434) | 1600434..1600643 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| OCX51_RS07770 (1600633) | 1600633..1600776 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| OCX51_RS07775 (1600805) | 1600805..1601581 | - | 777 | WP_001668987.1 | Rha family transcriptional regulator | - |
| OCX51_RS07780 (1601595) | 1601595..1601840 | - | 246 | WP_001573844.1 | helix-turn-helix transcriptional regulator | - |
| OCX51_RS07785 (1602032) | 1602032..1602361 | + | 330 | WP_001573842.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| OCX51_RS07790 (1602374) | 1602374..1602835 | + | 462 | WP_001573840.1 | phage protein | Toxin |
| OCX51_RS07795 (1602853) | 1602853..1603437 | + | 585 | WP_000825948.1 | hypothetical protein | - |
| OCX51_RS07800 (1603667) | 1603667..1603813 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| OCX51_RS07805 (1603810) | 1603810..1604424 | - | 615 | WP_000191459.1 | hypothetical protein | - |
| OCX51_RS07810 (1604550) | 1604550..1605755 | + | 1206 | WP_000264751.1 | site-specific integrase | - |
| OCX51_RS07815 (1605798) | 1605798..1607825 | - | 2028 | WP_001793477.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1560532..1623382 | 62850 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18060.43 Da Isoelectric Point: 4.6915
>T39406 WP_001573840.1 NZ_AP024742:1602374-1602835 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T39406 NZ_AP024742:1602374-1602835 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12730.33 Da Isoelectric Point: 6.4836
>AT39406 WP_001573842.1 NZ_AP024742:1602032-1602361 [Staphylococcus aureus]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 330 bp
>AT39406 NZ_AP024742:1602032-1602361 [Staphylococcus aureus]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCACTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAA
ACGTAAGTAA
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCACTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAA
ACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|