Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 847251..847728 Replicon chromosome
Accession NZ_AP024742
Organism Staphylococcus aureus strain 59736

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX51_RS04005 Protein ID WP_000052076.1
Coordinates 847251..847439 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX51_RS04010 Protein ID WP_001059690.1
Coordinates 847468..847728 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX51_RS03975 (843241) 843241..843762 + 522 WP_000824464.1 hypothetical protein -
OCX51_RS03980 (844103) 844103..844789 + 687 WP_117218907.1 thermonuclease family protein -
OCX51_RS03985 (845146) 845146..845346 + 201 WP_001059082.1 cold-shock protein -
OCX51_RS03990 (845842) 845842..846060 - 219 WP_000005886.1 hypothetical protein -
OCX51_RS03995 (846122) 846122..846406 - 285 WP_001004401.1 hypothetical protein -
OCX51_RS04000 (846494) 846494..847063 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX51_RS04005 (847251) 847251..847439 - 189 WP_000052076.1 hypothetical protein Toxin
OCX51_RS04010 (847468) 847468..847728 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX51_RS04015 (848068) 848068..848271 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX51_RS04020 (848268) 848268..848504 - 237 WP_000368687.1 hypothetical protein -
OCX51_RS04025 (848728) 848728..849309 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX51_RS04030 (849382) 849382..849999 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX51_RS04035 (850154) 850154..850648 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX51_RS04040 (851047) 851047..851469 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX51_RS04045 (851617) 851617..852333 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39402 WP_000052076.1 NZ_AP024742:c847439-847251 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39402 NZ_AP024742:c847439-847251 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39402 WP_001059690.1 NZ_AP024742:c847728-847468 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39402 NZ_AP024742:c847728-847468 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References