Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2205150..2205664 Replicon chromosome
Accession NZ_AP024738
Organism Staphylococcus aureus strain 59731

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag OCX20_RS11020 Protein ID WP_000581793.1
Coordinates 2205150..2205359 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OCX20_RS11025 Protein ID WP_000138932.1
Coordinates 2205371..2205664 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX20_RS11000 (2200659) 2200659..2202017 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OCX20_RS11005 (2202032) 2202032..2203102 - 1071 WP_261921281.1 D-alanine--D-alanine ligase -
OCX20_RS11010 (2203420) 2203420..2204622 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OCX20_RS11015 (2204885) 2204885..2205022 - 138 WP_000828354.1 Lmo0850 family protein -
OCX20_RS11020 (2205150) 2205150..2205359 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
OCX20_RS11025 (2205371) 2205371..2205664 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OCX20_RS11030 (2205830) 2205830..2207314 + 1485 WP_000571549.1 cardiolipin synthase -
OCX20_RS11035 (2207342) 2207342..2207989 + 648 WP_001187628.1 HD domain-containing protein -
OCX20_RS11040 (2208603) 2208603..2209475 - 873 WP_000725802.1 membrane protein insertase YidC -
OCX20_RS11045 (2209561) 2209561..2210202 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T39394 WP_000581793.1 NZ_AP024738:c2205359-2205150 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T39394 NZ_AP024738:c2205359-2205150 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT39394 WP_000138932.1 NZ_AP024738:c2205664-2205371 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT39394 NZ_AP024738:c2205664-2205371 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References