Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1600825..1601613 Replicon chromosome
Accession NZ_AP024738
Organism Staphylococcus aureus strain 59731

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag OCX20_RS07780 Protein ID WP_000525004.1
Coordinates 1601152..1601613 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag OCX20_RS07775 Protein ID WP_000333630.1
Coordinates 1600825..1601139 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX20_RS07715 (1595967) 1595967..1597133 - 1167 WP_064129389.1 DUF2800 domain-containing protein -
OCX20_RS07720 (1597130) 1597130..1597492 - 363 WP_000985976.1 hypothetical protein -
OCX20_RS07725 (1597507) 1597507..1597830 - 324 WP_000174994.1 hypothetical protein -
OCX20_RS07730 (1597909) 1597909..1598070 - 162 WP_001285963.1 DUF1270 family protein -
OCX20_RS07735 (1598083) 1598083..1598346 - 264 WP_001124159.1 helix-turn-helix domain-containing protein -
OCX20_RS07740 (1598371) 1598371..1598586 - 216 WP_001097552.1 hypothetical protein -
OCX20_RS07745 (1598641) 1598641..1599006 + 366 WP_001128433.1 hypothetical protein -
OCX20_RS07750 (1598975) 1598975..1599220 - 246 WP_001025401.1 DUF2829 domain-containing protein -
OCX20_RS07755 (1599276) 1599276..1599485 + 210 WP_000642492.1 hypothetical protein -
OCX20_RS07760 (1599475) 1599475..1599618 - 144 WP_000939498.1 hypothetical protein -
OCX20_RS07765 (1599647) 1599647..1600423 - 777 WP_001148544.1 Rha family transcriptional regulator -
OCX20_RS07770 (1600437) 1600437..1600673 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
OCX20_RS07775 (1600825) 1600825..1601139 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
OCX20_RS07780 (1601152) 1601152..1601613 + 462 WP_000525004.1 hypothetical protein Toxin
OCX20_RS07785 (1601631) 1601631..1602215 + 585 WP_000825948.1 hypothetical protein -
OCX20_RS07790 (1602445) 1602445..1602591 + 147 WP_072433242.1 hypothetical protein -
OCX20_RS07795 (1602588) 1602588..1603202 - 615 WP_000191466.1 hypothetical protein -
OCX20_RS07800 (1603328) 1603328..1604533 + 1206 WP_000264747.1 site-specific integrase -
OCX20_RS07805 (1604576) 1604576..1606603 - 2028 WP_117219080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1556064..1622159 66095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T39386 WP_000525004.1 NZ_AP024738:1601152-1601613 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T39386 NZ_AP024738:1601152-1601613 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT39386 WP_000333630.1 NZ_AP024738:1600825-1601139 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT39386 NZ_AP024738:1600825-1601139 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References