Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 847675..848152 Replicon chromosome
Accession NZ_AP024738
Organism Staphylococcus aureus strain 59731

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX20_RS04015 Protein ID WP_000052076.1
Coordinates 847675..847863 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX20_RS04020 Protein ID WP_001059690.1
Coordinates 847892..848152 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX20_RS03985 (843665) 843665..844186 + 522 WP_000824464.1 hypothetical protein -
OCX20_RS03990 (844527) 844527..845213 + 687 WP_117218907.1 thermonuclease family protein -
OCX20_RS03995 (845570) 845570..845770 + 201 WP_001059082.1 cold-shock protein -
OCX20_RS04000 (846266) 846266..846484 - 219 WP_000005886.1 hypothetical protein -
OCX20_RS04005 (846546) 846546..846830 - 285 WP_001004401.1 hypothetical protein -
OCX20_RS04010 (846918) 846918..847487 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX20_RS04015 (847675) 847675..847863 - 189 WP_000052076.1 hypothetical protein Toxin
OCX20_RS04020 (847892) 847892..848152 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX20_RS04025 (848492) 848492..848695 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX20_RS04030 (848692) 848692..848928 - 237 WP_000368687.1 hypothetical protein -
OCX20_RS04035 (849152) 849152..849733 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX20_RS04040 (849806) 849806..850423 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX20_RS04045 (850578) 850578..851072 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX20_RS04050 (851471) 851471..851893 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX20_RS04055 (852041) 852041..852757 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39382 WP_000052076.1 NZ_AP024738:c847863-847675 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39382 NZ_AP024738:c847863-847675 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39382 WP_001059690.1 NZ_AP024738:c848152-847892 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39382 NZ_AP024738:c848152-847892 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References