Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2192846..2193360 Replicon chromosome
Accession NZ_AP024736
Organism Staphylococcus aureus strain 59709

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag OCX48_RS10975 Protein ID WP_000581793.1
Coordinates 2192846..2193055 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OCX48_RS10980 Protein ID WP_000138932.1
Coordinates 2193067..2193360 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX48_RS10955 (2188355) 2188355..2189713 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OCX48_RS10960 (2189728) 2189728..2190798 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
OCX48_RS10965 (2191116) 2191116..2192318 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OCX48_RS10970 (2192581) 2192581..2192718 - 138 WP_000828354.1 Lmo0850 family protein -
OCX48_RS10975 (2192846) 2192846..2193055 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
OCX48_RS10980 (2193067) 2193067..2193360 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OCX48_RS10985 (2193526) 2193526..2195010 + 1485 WP_000571549.1 cardiolipin synthase -
OCX48_RS10990 (2195038) 2195038..2195685 + 648 WP_001187628.1 HD domain-containing protein -
OCX48_RS10995 (2196299) 2196299..2197171 - 873 WP_000725802.1 membrane protein insertase YidC -
OCX48_RS11000 (2197257) 2197257..2197898 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T39374 WP_000581793.1 NZ_AP024736:c2193055-2192846 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T39374 NZ_AP024736:c2193055-2192846 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT39374 WP_000138932.1 NZ_AP024736:c2193360-2193067 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT39374 NZ_AP024736:c2193360-2193067 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References