Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 848037..848514 Replicon chromosome
Accession NZ_AP024736
Organism Staphylococcus aureus strain 59709

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX48_RS04020 Protein ID WP_000052076.1
Coordinates 848037..848225 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX48_RS04025 Protein ID WP_001059690.1
Coordinates 848254..848514 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX48_RS03990 (844027) 844027..844548 + 522 WP_000824464.1 hypothetical protein -
OCX48_RS03995 (844889) 844889..845575 + 687 WP_117218907.1 thermonuclease family protein -
OCX48_RS04000 (845932) 845932..846132 + 201 WP_001059082.1 cold-shock protein -
OCX48_RS04005 (846628) 846628..846846 - 219 WP_000005886.1 hypothetical protein -
OCX48_RS04010 (846908) 846908..847192 - 285 WP_001004401.1 hypothetical protein -
OCX48_RS04015 (847280) 847280..847849 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX48_RS04020 (848037) 848037..848225 - 189 WP_000052076.1 hypothetical protein Toxin
OCX48_RS04025 (848254) 848254..848514 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX48_RS04030 (848854) 848854..849057 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX48_RS04035 (849054) 849054..849290 - 237 WP_000368687.1 hypothetical protein -
OCX48_RS04040 (849514) 849514..850095 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX48_RS04045 (850168) 850168..850785 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX48_RS04050 (850940) 850940..851434 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX48_RS04055 (851833) 851833..852255 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX48_RS04060 (852403) 852403..853119 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ant(9)-Ia / erm(A) - 842670..861267 18597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39362 WP_000052076.1 NZ_AP024736:c848225-848037 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39362 NZ_AP024736:c848225-848037 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39362 WP_001059690.1 NZ_AP024736:c848514-848254 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39362 NZ_AP024736:c848514-848254 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References